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2 810 261

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IPC

A61K31/405(2006-01-01)

A61K36/54(2006-01-01)

A61K47/14(2006-01-01)

A61K47/24(2006-01-01)

A61K9/127(2006-01-01)

A61P31/12(2006-01-01)

(21) (22)

Application

2023109702, 2023-04-14

(24)

Start date

2023-04-14

(22)

Actual filing date

2023-04-14

(45)

Published

2023-12-25

(72)

Inventor

Kirillov Igor AnatolevichVolkov Vitalij LeonardovichBelyaev Artur SergeevichIllarionov Vladimir VladimirovichPredtechenskij Aleksandr BorisovichKovtun Viktor AleksandrovichMosin Nikita IgorevichMuradov Mikhail MikhajlovichMakacheev Aleksandr SergeevichShevchenko Elena ViktorovnaOstroumov Yurij IgorevichGorokhovskaya Irina NikolaevnaShmelin Pavel SergeevichLozanov Ivan AlekseevichBorisevich Sergej VladimirovichLoginova Svetlana YakovlevnaShchukina Veronika NikolaevnaSavenko Sergej Vadimovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchnyj Tsentr" Ministerstva Oborony Rossijskoj Federatsii

LIPOSOMAL COMPOSITION OF 5-CHLOROPYRIDIN-3-IL-1H-INDOL-4-CARBOXYLATE AS A POTENTIAL EMERGENCY PREVENTION AND TREATMENT OF CORONAVIRUS INFECTIONS Russian patent published in 2023 - IPC A61K31/405 A61K36/54 A61K47/14 A61K47/24 A61K9/127 A61P31/12

Abstract RU 2810261 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to a liposomal composition with activity against SARS-CoV-2. Liposomal composition with activity against SARS-CoV-2 with improved bioavailability, cytotoxicity and therapeutic efficacy when taken orally, containing 5-chloropyridin-3-yl-1H-indole-4-carboxylate as the active component, as well as phosphatidylethanolamine, oil avocado and a mixture of methylparaben and propyl-paraben as a preservative in the following ratio of components, wt.%: water 95.0÷97.0; 5-chloropyridin-3-yl-1H-indole-4-carboxylate 0.15÷0.2; avocado oil 1.0÷3.0; phospholipids 0.6÷0.8; methylparaben 0.04÷0.05; propylparaben 0.04÷0.05.

EFFECT: above composition is a water-soluble form of 5-chloropyridin-3-yl-1H-indole-4-carboxylate encapsulated in liposomes with improved oral bioavailability, reduced cytotoxicity and improved therapeutic efficacy.

1 cl, 1 tbl, 1 ex

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RU 2 810 261 C1

Authors

Kirillov Igor Anatolevich

Volkov Vitalij Leonardovich

Belyaev Artur Sergeevich

Illarionov Vladimir Vladimirovich

Predtechenskij Aleksandr Borisovich

Kovtun Viktor Aleksandrovich

Mosin Nikita Igorevich

Muradov Mikhail Mikhajlovich

Makacheev Aleksandr Sergeevich

Shevchenko Elena Viktorovna

Ostroumov Yurij Igorevich

Gorokhovskaya Irina Nikolaevna

Shmelin Pavel Sergeevich

Lozanov Ivan Alekseevich

Borisevich Sergej Vladimirovich

Loginova Svetlana Yakovlevna

Shchukina Veronika Nikolaevna

Savenko Sergej Vadimovich

Dates

2023-12-25—Published

2023-04-14—Filed