FIELD: biotechnology.
SUBSTANCE: invention relates to production of immunocytokines with interleukin-2, and can be used in medicine for treating cancer. Presented is an anti-tumor fusion protein containing a whole anti-PDL1 antibody as a therapeutic protein coupled with a mutant interleukin-2 (IL2) polypeptide. Mutant IL2 polypeptide is linked to the C-ends of each heavy chain of the antibody by a serine-glycine linker sequence.
EFFECT: invention provides obtaining immunocytokine with high anticancer potential, capable of selectively inducing preferential proliferation of CD8+T-cells and NK-cells relative to T-reg cells.
7 cl, 13 dwg, 11 tbl, 10 ex
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