POLYVALENT AND POLYSPECIFIC OX40-BINDING FUSED PROTEINS Russian patent published in 2022 - IPC C07K16/28 C07K16/46 C07K19/00 C12N15/09 A61K39/395 A61P35/00 A61P37/02 A61P29/00 

Abstract RU 2773052 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, specifically to molecules that specifically bind OX40, a TNF receptor superfamily (TNFRSF) representative; it can be used in medicine for the treatment of neoplasms.

EFFECT: proposed polypeptide contains a set of VHH domains binding OX40, and it is capable of modulating immune cells in order to enhance tumor destruction.

17 cl, 14 dwg, 3 ex

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RU 2 773 052 C2

Authors

Ekelman Brendan P.

Timmer Dzhon K.

Khata Chelsi

Dzhons Kajl S.

Khussejn Abrakhim

Razai Amir S.

Beklund Brajan

Pandit Radzhaj

Kaplan Majk

Reskon Lukas

Devero Kuinn

Dates

2022-05-30Published

2017-01-11Filed