FIELD: biotechnology and medicine.
SUBSTANCE: invention relates to a method of producing a bioactive kidney cell (BKC), including a genetic modification in the beta-2 microglobulin (B2M) gene to provide a regenerative effect on a natural kidney for the treatment of chronic renal failure.
EFFECT: invention makes it possible to obtain a population of “universal donor” immunologically privileged kidney cells, to which gene editing was applied to obtain a population of modified allogeneic kidney cells administered to patients without the use of immunosuppression.
44 cl, 16 dwg, 9 tbl, 6 ex
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