TRIAZINE DERIVATIVES FOR TREATING DISEASES ASSOCIATED WITH NEUROTROPHINS Russian patent published in 2024 - IPC C07D251/30 C07D251/34 C07D401/04 C07D403/04 C07D405/04 C07D409/04 C07D417/04 A61K31/53 A61K31/5377 A61P25/00 A61P25/24 A61P25/16 A61P25/28 

Abstract RU 2816837 C2

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to pharmaceutically active compounds. Disclosed is a compound of formula I, where R1, R2, n, X, Q, L, m, R3 and p are as defined by the claims. Also disclosed are embodiments of a method of producing said compound, embodiments of using said compound for producing a drug for treating diseases characterized by disturbed signalling pathways of neurotrophins and/or other trophic factors, and for the treatment of a disease characterized by disturbed signalling pathways of neurotrophins and/or other trophic factors, as well as a pharmaceutical composition containing a compound of formula I, and a method of treating said diseases using the disclosed compound.

EFFECT: disclosed compound is a positive modulator of receptors TRK A, TRK B and TRK C and receptor tyrosine kinases IGF1R and FGF1R.

21 cl, 1 dwg, 1 tbl, 78 ex

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RU 2 816 837 C2

Authors

Nordvall, Gunnar

Forsell, Pontus

Dates

2024-04-05Published

2019-02-26Filed