FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, namely to a polypeptide for binding to human FcRn, which binds to human FcRn with Kd 1×10-6 M or less at pH 6.0, method of its production, as well as to a composition containing it. Also disclosed is a polynucleotide coding said polypeptide, as well as a vector, a plasmid, a minicircle, a host cell containing said polypeptide.
EFFECT: invention is effective for increasing the half-life of the therapeutic molecule from blood serum.
20 cl, 9 dwg, 6 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROGRAMMED CELL DEATH (PD-1) PROTEIN-1 ANTIBODIES AND USE THEREOF | 2017 |
|
RU2725950C1 |
| NEW VERSIONS OF HYALURONIDASE WITH IMPROVED STABILITY AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM | 2021 |
|
RU2811464C2 |
| NEW O-SUCCINYL HOMOSERINE TRANSFERASE VARIANT AND METHOD FOR SYNTHESIS OF O-SUCCINYL HOMOSERINE USING SAID VARIANT | 2018 |
|
RU2747493C1 |
| ANTIBODIES AGAINST LIGAND-1 PROGRAMMED DEATH (PD-L1) AND APPLICATION THEREOF | 2017 |
|
RU2721582C1 |
| NEW O-SUCCINYL HOMOSERINE TRANSFERASE MUTANT AND METHOD FOR SYNTHESIS OF O-SUCCINYL HOMOSERINE USING SAID MUTANT | 2018 |
|
RU2747494C1 |
| ANTI-PVRIG ANTIBODIES AND METHODS OF USING | 2016 |
|
RU2732042C2 |
| BISPECIFIC ANTIBODIES | 2020 |
|
RU2818588C2 |
| POLYPEPTIDE COMPRISING ANTIGEN-BINDING DOMAIN AND TRANSPORT SEGMENT | 2018 |
|
RU2815452C2 |
| MICROORGANISM PRODUCING MYCOSPORINE-LIKE AMINO ACID AND METHOD FOR PRODUCING MYCOSPORINE-LIKE AMINO ACID USING SAID MICROORGANISM | 2019 |
|
RU2757424C1 |
| VARIANT OF ALDOLASE AROG AND METHOD OF PRODUCING BRANCHED-CHAIN AMINO ACID USING SAME | 2021 |
|
RU2826456C1 |
