ALDOSE REDUCTASE INHIBITORS AND METHODS OF THEIR APPLICATION Russian patent published in 2023 - IPC C07D495/04 A61K31/5025 A61P17/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where R¹ represents CO₂R²; R² is H, (C₁-C₆)-alkyl or (C₁-C₆)-aminoalkyl; X¹ and X² are H; Y is C=O; Z represents or; A¹ is S; A² is N; A³ is O; and R³-R⁶ are independently hydrogen, halogen or haloalkyl. The invention also relates to specific compounds and a pharmaceutical composition based on a compound of formula (I) or a specific compound.

EFFECT: effective inhibition of aldoreductase activity in the treatment of such diseases as diabetes, neuropathy, retinopathy, nephropathy and cardiomyopathy.

38 cl, 1 tbl, 17 ex