FIELD: pharmaceutics.
SUBSTANCE: present invention relates to new methyl-3-aryl-3a-nitro-4-(trifluoromethyl)-1,2,3,3a,4,9b-hexahydrochromeno[3,4-c]pyrrole-1-carboxylateam of general formula I, where: R1 is H, alkoxy C1-C6, Br, Cl; -R2 is H, alkoxy C1-C6, Br, Cl; -Ar is Ph, 4-MeOC6H4, 3,4-(MeO)2C6H3, 2,3,4-(MeO)3C6H2, benzo[d][1,3]dioxol-5-yl, which exhibit cytotoxic activity with respect to human cervical carcinoma cells HeLa, and a method for production thereof.
EFFECT: disclosed is a highly efficient regio- and stereoselective method of producing methyl-3-aryl-3a-nitro-4-(trifluoromethyl)-1,2,3,3a,4,9b-hexahydrochromeno[3,4-c]pyrrole-1-carboxylates, which have cytotoxic activity with respect to human cervical carcinoma cells HeLa and are potential anticancer drugs.
2 cl, 1 dwg, 2 tbl, 10 ex
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