6-TRIFLUORO(TRICHLORO)METHYL-SUBSTITUTED SPIRO[CHROMENO[3,4-a]PYRROLIZIDINE-11,3'-INDOLINE]-2'-ONES SHOWING ANTITUMOR ACTIVITY, AND THEIR PRODUCTION METHOD Russian patent published in 2022 - IPC C07D491/107 A61K31/4162 A61P35/00 

FIELD: organic chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to the field of organic chemistry and pharmaceutics, and it is aimed at the production of compounds, which show antitumor activity. The invention is presented by new 6-trifluoro(trichloro)methyl-substituted spiro[chromeno[3,4-a]pyrrolizidine-11,3'-indoline]-2'-one of the general formula I, where R¹ is H, C1-C6 alkyl, C1-C6 alkoxy, Br, Cl, NO₂; R² is H, C1-C6 alkyl, C1-C6 alkoxy, Br, Cl, NO₂; R³ is H, C1-C6 alkyl, Bn, X is F, Cl. In addition, a method is described for the production of 6-trifluoro(trichloro)methyl-substituted spiro[chromeno[3,4-a]pyrrolizidine-11,3'-indoline]-2'-ones of the general formula I.

EFFECT: high-effective regio- and stereo-selective method for the production of 6-trifluoro(trichloro)methyl-substituted spiro[chromeno[3,4-a]pyrrolizidine-11,3'-indoline]-2'-ones, which have cytotoxic activity relatively to cell lines of human cervix carcinoma (HeLa) and human embryonic rhabdomyosarcoma (RD).

2 cl, 1 dwg, 2 tbl, 25 ex