COMPOSITIONS AND METHODS FOR REDUCING SIGNIFICANT THROMBOTIC EVENTS IN PATIENTS WITH MALIGNANT TUMOR Russian patent published in 2024 - IPC A61K31/352 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: present invention relates to a method for reducing or preventing thrombus formation in a patient with a malignant tumor, comprising administering to a patient an effective amount of isoquercetin, vitamin B3 and vitamin C for a period of at least 2 months; wherein the patient is diagnosed with cancer and is contraindicated for thrombosis prevention; and he has an increased level of soluble P-selectin before administration of isoquercetin, when compared to a reference or initial level of soluble P-selectin; where the dose of isoquercetin is 500 mg per day, wherein the patient does not have primary venous thromboembolism (VTE) during treatment or after administration of an effective amount of isoquercetin, vitamin B3 and vitamin C for a period of at least 2 months; and wherein soluble P-selectin is reduced by at least 30% when compared to a reference or initial level of soluble P-selectin after administration of isoquercetin.

EFFECT: present invention provides a significant reduction in circulating soluble P-selectin and thrombocyte-dependent formation of thrombin when administering 500 mg of isoquercetin, and no significant bleeding is observed.

6 cl, 6 dwg, 1 tbl