MACROCYCLIC COMPOUND Russian patent published in 2024 - IPC C07D498/22 A61K31/506 A61P3/00 A61P29/00 A61P35/00 A61P37/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a compound represented by general formula (1), or a pharmaceutically acceptable salt thereof, in formula (1) R¹ is -H or C_1-6 alkyl; R² is -H or C_1-6 alkyl; R³ is -H or C_1-6 alkyl; Ar is 6–10-membered aryl or 5–10-membered heteroaryl containing 2 heteroatoms selected from O, S and N, where Ar can be substituted with 1 substituent selected from group G²; group G² is a group of substitutes consisting of C_1-6 alkyl, hydroxy-C_1-6 alkyl, R^Ar1-OC_1-3 alkyl; R^Ar1 is -H, C_1-6 alkyl, or 3–7-membered saturated hydrocarbon ring, R^Ar1 can be substituted with 1–2 identical or different substitutes selected from group G³; group G³ is a group of substitutes consisting of a hydroxyl group and 3–7 membered saturated hydrocarbon ring group; X¹ is N or CH; X² is NH or O; X³ is a group represented by general formula (1-1), general formula (1-2) or formula (1-3) given below, a and b represent the direction of attachment; R²¹ and R²² independently represent -H; X⁴ is a group represented by general formula (2-1), b and c represent the direction of attachment; in formula (2-1), n is integer from 1 to 3; Y is NR⁵¹ or O; R³¹ and R³² independently represent -H, C_1-3 alkyl; R⁴¹ and R⁴² independently represent -H, -F, C_1-3 alkyl; or R⁴¹ and R⁴² can be combined to form 3–6 membered saturated hydrocarbon ring; R⁵¹ is H or C_1-3 alkyl; 1 or R⁵¹ and R³¹ can be combined to form 4–6-membered saturated heterocyclic ring containing one heteroatom selected from N.

EFFECT: novel compound which can be used in medicine for treating IRAK-4-mediated diseases is obtained.

11 cl, 7 tbl, 70 ex