OBTAINING AND USING TRICYCLIC PYRIMIDINONE COMPOUND AND COMPOSITION THEREOF Russian patent published in 2024 - IPC C07D498/16 A61K31/5383 A61P13/08 A61P25/28 A61P27/06 A61P9/00 A61P3/10 

FIELD: organic chemistry.

SUBSTANCE: group of inventions includes a compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for production thereof, a pharmaceutical composition containing said compound and use thereof. In formula (I) each n₁, n₂ and n₃ is independently 0, 1 or 2; each R₁ and R₂ is independently selected from -H, alkyl, deuterated alkyl, haloalkyl; each X₁ and X₂ independently represents -O-; Ar is an arylene group, where hydrogen atoms in arylene are substituted with 0, 1, 2 or 3 substituents, and each of the substituents is independently selected from halogen, alkyl, deuteroalkyl, haloalkyl; Y is -H, halogen, -OAr'; Ar' is selected from 6–10-membered aryl or 5–6-membered heteroaryl containing 1–2 N atoms, where the hydrogen atoms in the aryl or heteroaryl are substituted with 1 or 2 substitutes, each of which is independently selected from halogen, alkyl, deuterated alkyl, haloalkyl, alkoxy, deuterated alkoxy, haloalkoxy; Z is O or S; each halogen in "halogen", "haloalkyl" and "haloalkoxy" is independently selected from F, Cl, Br or I; each alkyl in "alkyl", "deuterated alkyl", "haloalkyl", "haloalkoxy", "deuterated alkoxy", "alkoxy" is independently C₁-C₇ linear or branched alkyl; each "alkylene" is independently C₁-C₇ linear or branched alkylene; "arylene" is 6–10 membered arylene.

EFFECT: compound of formula (I) as an Lp-PLA2 inhibitor.

44 cl, 2 tbl, 19 ex