TETRACYCLIC PYRIMIDINONE COMPOUND, A METHOD OF ITS PREPARATION, AS WELL AS ITS COMPOSITION AND USE Russian patent published in 2023 - IPC C07D487/04 C07D487/14 C07D487/22 C07D498/22 A61K31/519 A61P3/10 A61P9/10 A61P13/08 A61P25/28 A61P27/02 A61P27/06 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof.

The invention also relates to a pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof having the property of an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), and also relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt or pharmaceutical composition thereof for the preparation of Lp-PLA2 inhibitor, also relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt or pharmaceutical composition thereof for the preparation of a medicinal product for the treatment of a neurodegeneration-related disease, also relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt or pharmaceutical composition thereof for the preparation of a medicinal product for the treatment of cardiovascular disease, diabetic macular edema (DME) or prostate disease.

EFFECT: group of inventions ensures the development of the synthesis of new tetracyclic pyrimidinones compounds as alternative inhibitors of lipoprotein-associated phospholipase A2 (Lp-PLA2).

27 cl, 2 tbl, 20 ex