BRIDGED PYRIMIDINONE COMPOUNDS AND METHODS FOR PREPARATION, COMPOSITIONS AND USE THEREOF Russian patent published in 2024 - IPC C07D471/18 C07D498/18 A61K31/529 A61K31/5386 A61P13/08 A61P25/28 A61P27/06 A61P3/10 A61P9/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof:

(I),

where n₁, n₂ and n₃ are each independently equal to 1; R₁ and R₂ each independently represents -H; X₁ is selected from -CH₂- or -O-; X₂ is selected from -O-; Ar is phenylene, where each of the hydrogen atoms in said phenylene is optionally substituted with 1, 2 or 3 substituents and each of the substituents is independently selected from halogen; Y is -H, halogen or -OAr'; Ar' is selected from phenyl, pyridyl or pyrimidinyl, where hydrogen atoms in phenyl, pyridyl or pyrimidinyl are optionally substituted with 1 or 2 substituents, each independently selected from halogen, C₁-C₄alkyl, C₁-C₄haloalkyl, C₁-C₄alkoxy or C₁-C₄haloalkoxy; Z is O; and wherein the halogens in halogen, C₁-C₄haloalkyl and C₁-C₄haloalkoxy are each independently selected from F, Cl, Br or I, as well as to a method for production thereof, pharmaceutical composition and use of the compound of formula (I) for preparing a drug for treating diseases for inhibiting Lp-PLA2.

EFFECT: novel compounds which can be used for inhibiting Lp-PLA2 and treating mediated diseases are obtained.

13 cl, 2 tbl, 40 ex