ENZYME INHIBITORS Russian patent published in 2018 - IPC C07D401/10 C07D401/12 C07D401/14 C07D403/10 C07D403/14 C07D413/14 C07D417/14 C07D471/04 A61K31/455 A61K31/4725 A61K31/496 A61K31/538 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound according to formula I, in which B is a or B is a condensed 6,5- or 6,6-heteroaromatic bicycle containing N and, optionally, one additional heteroatom selected from N, which is an optionally mono- or disubstituted substituent selected from alkyl and NR8R9; W, X, Y, and Z are independently selected from C, C(R16)-C, C(R16)=C, C=N, and N, so that the cycle containing W, X, Y, and Z is a six-membered aromatic heterocycle; or a cycle containing W, X, Y, and Z is , R5, R6, and R7 are independently absent or are independently selected from H, alkyl, alkoxy, OH, and -NR8R9; A is selected from aryl, heteroaryl and a substituent of the formula (A), (B), (C) and (D). Values of other substitutes are specified in the patent claim. Invention also relates to a pharmaceutical composition, to the use of a compound, to a method of treating a disease or condition. Formula (I)

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EFFECT: technical result: new compounds with activity to inhibit plasma kallikrein are obtained.

27 cl, 13 tbl, 96 ex