MESOTHELINIC CAR RECEPTORS AND USE THEREOF Russian patent published in 2024 - IPC C07K14/705 C07K16/28 C07K16/30 A61K39/00 A61P35/00

Abstract RU 2822193 C2

FIELD: biotechnology.

SUBSTANCE: there are presented: a polypeptide composition specifically interacting with human mesothelin, an immunoreactive cell for enhancing the immune response to cancer and a method for preparing the same, a pharmaceutical composition for enhancing the immune response to cancer, a nucleic acid composition for producing an immunoreactive cell and an expression vector. Also disclosed is a kit for enhancing the immune response to cancer, a method of treating neoplasia in a subject and treating a subject having a recurrent neoplasia, method of increasing or prolonging the survival rate of a subject having neoplasia, a method of reducing a tumour load in a subject, a method of increasing production of an immunoactivating cytokine in response to a cancer cell or a pathogen in a subject, a method of treating an inflammatory disease in a subject and a method for preventing transplant rejection in a subject.

EFFECT: invention is used to enhance the immune response to cancer, as well as to increase the production of an immunoactivating cytokine in response to a cancer cell or pathogen in a subject.

90 cl, 13 tbl, 94 dwg, 6 ex

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RU 2 822 193 C2

Authors

Adusumilli, Prasad, S.

Sadelain, Michel

Dates

2024-07-03—Published

2020-05-18—Filed