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(19)

RU

(11)

2 823 298

(13)

C1

(51)

IPC

C07C219/06(2006-01-01)

A61K9/127(2006-01-01)

A61K9/51(2006-01-01)

A61K31/7088(2006-01-01)

A61K31/7105(2006-01-01)

A61K47/18(2006-01-01)

B82Y5/00(2011-01-01)

(21) (22)

Application

2023129493, 2023-11-14

(24)

Start date

2023-11-14

(22)

Actual filing date

2023-11-14

(45)

Published

2024-07-22

(72)

Inventor

Boldyrev Ivan AleksandrovichShendrikov Valerij PavlovichKislova Svetlana OlegovnaAndreev Dmitrij EvgenevichPoteshnova Mariya ViktorovnaRubtsova Mariya PetrovnaRubtsov Yurij PetrovichVodovozova Elena Lvovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Gosudarstvennyj Nauchnyj Tsentr Rossijskoj Federatsii Institut Bioorganicheskoj Khimii Im. Akademikov M.M. Shemyakina I Yu.A. Ovchinnikova Rossijskoj Akademii Nauk Ibkh Ran)

IONISABLE CATIONIC LIPIDS FOR NUCLEIC ACID DELIVERY Russian patent published in 2024 - IPC C07C219/06 A61K9/127 A61K9/51 A61K31/7088 A61K31/7105 A61K47/18 B82Y5/00 

Abstract RU 2823298 C1

FIELD: chemistry.

SUBSTANCE: invention relates to binary diglyceride derivatives of tertiary alkylamines of general formula given below, which can be used as ionisable cationic lipids for designing lipid nanoparticles for RNA delivery into cells and an organism. In said general formula, R denotes an unbranched alkyl residue of fatty acids of the limit series C7H15, C9H19, C11H23; n = 3, 4; m = 1, 3.

EFFECT: invention also relates to a lipid nanoparticle for delivery of RNA into cells and an organism, containing RNA and said binary diglyceride derivatives of tertiary alkylamines, and to its use for delivery and expression of mRNA into cells and an organism.

3 cl, 3 dwg, 2 tbl, 5 ex

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RU 2 823 298 C1

Authors

Boldyrev Ivan Aleksandrovich

Shendrikov Valerij Pavlovich

Kislova Svetlana Olegovna

Andreev Dmitrij Evgenevich

Poteshnova Mariya Viktorovna

Rubtsova Mariya Petrovna

Rubtsov Yurij Petrovich

Vodovozova Elena Lvovna

Dates

2024-07-22—Published

2023-11-14—Filed

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