FIELD: chemistry.
SUBSTANCE: invention relates to binary diglyceride derivatives of tertiary alkylamines of general formula given below, which can be used as ionisable cationic lipids for designing lipid nanoparticles for RNA delivery into cells and an organism. In said general formula, R denotes an unbranched alkyl residue of fatty acids of the limit series C7H15, C9H19, C11H23; n = 3, 4; m = 1, 3.
EFFECT: invention also relates to a lipid nanoparticle for delivery of RNA into cells and an organism, containing RNA and said binary diglyceride derivatives of tertiary alkylamines, and to its use for delivery and expression of mRNA into cells and an organism.
3 cl, 3 dwg, 2 tbl, 5 ex
Title |
Year |
Author |
Number |
CATIONIC LIPID FOR DELIVERY OF NUCLEIC ACIDS INTO MAMMALIAN CELLS, METHOD FOR PRODUCTION THEREOF AND USE THEREOF |
2024 |
- Gintsburg Aleksandr Leonidovich
- Logunov Denis Iurevich
- Gushchin Vladimir Alekseevich
- Ivanov Roman Alekseevich
- Kovalchuk Sergei Igorevich
- Tukhvatulina Natalia Mikhailovna
- Kleimenov Denis Aleksandrovich
- Dzharullaeva Alina Shakhmirovna
- Bykonia Evgeniia Nikolaevna
- Mazunina Elena Petrovna
- Ivanov Igor Andreevich
- Karp Olga Edvinovna
- Verdiev Bakhtiiar Israil Ogly
- Pochtovyi Andrei Andreevich
- Shcherbinin Dmitrii Nikolaevich
- Usachev Evgenii Valerevich
- Vasina Daria Vladimirovna
- Tukhvatulin Amir Ildarovich
- Dmitriev Sergei Evgenevich
- Kuznetsova Nadezhda Anatolevna
- Siniavin Andrei Eduardovich
- Kozlova Sofia Rubenovna
- Antonova Nataliia Petrovna
- Shidlovskaia Elena Vladimirovna
- Tutykhina Irina Leonidovna
- Egorova Daria Andreevna
- Remizov Timofei Andreevich
- Zakharova Anastasiia Andreevna
- Bogdanov Andrei Iurevich
- Karpov Andrei Pavlovich
- Semikhin Aleksandr Sergeevich
- Gosudarev Andrei Igorevich
- Tokarskaia Elizaveta Aleksandrovna
- Lubenets Nadezhda Leonidovna
- Vereveiko Iuliia Romanovna
- Komiakova Marina Evgenevna
- Erokhova Alina Sergeevna
- Ungur Anastasiia Sergeevna
|
RU2836309C1 |
MULTI-EPITOPE POLYPEPTIDE FOR IMMUNIZATION AGAINST MYCOBACTERIUM TUBERCULOSIS |
2023 |
- Ivanov Roman Alekseevich
- Reshetnikov Vasilij Vladimirovich
- Muslimov Albert Radikovich
|
RU2824195C1 |
SORAFENIB-BASED COMBINATION THERAPY FOR HEPATOCELLULAR CARCINOMA |
2022 |
- Sergeeva Olga Vladimirovna
- Abakumova Tatyana Olegovna
- Vetosheva Polina Igorevna
- Zatsepin Timofej Sergeevich
|
RU2800071C1 |
RNA STRUCTURES AND APPLICATION THEREOF |
2021 |
- Sahin, Ugur
- Guler, Alptekin
- Kuhn, Andreas
- Muik, Alexander
- Vogel, Annette
- Walzer, Kerstin
- Witzel, Sonja
- Hein, Stephanie
- Tureci, Ozlem
- Boros, Gabor
- Mahiny, Azita Josefine
- Reinholz, Jonas
- Kariko, Katalin
|
RU2838444C1 |
ANTICANCER RNA VACCINES |
2017 |
- Valiante, Nicholas
- Ashburn, Ted
- Hopson, Kristen
|
RU2768829C2 |
NUCLEIC ACID CONTAINING REGULATORY ELEMENTS OF RABBIT β-GLOBIN GENE, mtRNR1 AND EMCV |
2023 |
- Ivanov Roman Alekseevich
- Reshetnikov Vasilii Vladimirovich
- Terenin Ilia Mikhailovich
|
RU2831165C1 |
NUCLEIC ACID CONTAINING REGULATORY ELEMENTS OF RABBIT β-GLOBIN GENE, mtRNR1 AND AES |
2023 |
- Ivanov Roman Alekseevich
- Reshetnikov Vasilij Vladimirovich
- Vasileva Olga Olegovna
|
RU2831164C1 |
NUCLEIC ACID CONTAINING REGULATORY ELEMENTS H4C2, AES AND MTRNR1 |
2023 |
- Ivanov Roman Alekseevich
- Reshetnikov Vasilij Vladimirovich
- Vasileva Olga Olegovna
|
RU2831168C1 |
NUCLEIC ACID CONTAINING REGULATORY ELEMENTS TPL, AES AND mtRNR1 |
2023 |
- Ivanov Roman Alekseevich
- Reshetnikov Vasilij Vladimirovich
- Vasileva Olga Olegovna
|
RU2831163C1 |
TRINUCLEOTIDE CAPPING REAGENT, METHOD FOR ITS PREPARATION AND USE |
2024 |
- Gintsburg Aleksandr Leonidovich
- Logunov Denis Yurevich
- Gushchin Vladimir Alekseevich
- Dolgushin Sergej Anatolevich
- Shalaev Pavel Vladimirovich
- Verdiev Bakhtiyar Israil Ogly
- Ivanov Roman Alekseevich
- Klejmenov Denis Aleksandrovich
- Bykonya Evgeniya Nikolaevna
- Mazunina Elena Petrovna
- Dzharullaeva Alina Shakhmirovna
- Pochtovyj Andrej Andreevich
- Sinyavin Andrej Eduardovich
- Usachev Evgenij Valerevich
- Vasina Darya Vladimirovna
- Kuznetsova Nadezhda Anatolevna
- Dmitriev Sergej Evgenevich
- Ivanov Igor Andreevich
- Tutykhina Irina Leonidovna
- Remizov Timofej Andreevich
- Zakharova Anastasiya Andreevna
- Semikhin Aleksandr Sergeevich
- Gosudarev Andrej Igorevich
- Egorova Darya Andreevna
- Shcherbinin Dmitrij Nikolaevich
- Tokarskaya Elizaveta Aleksandrovna
- Lubenets Nadezhda Leonidovna
- Tukhvatulina Natalya Mikhajlovna
|
RU2829515C1 |