IONISABLE CATIONIC LIPIDS FOR NUCLEIC ACID DELIVERY Russian patent published in 2024 - IPC C07C219/06 A61K9/127 A61K9/51 A61K31/7088 A61K31/7105 A61K47/18 B82Y5/00 

Abstract RU 2823298 C1

FIELD: chemistry.

SUBSTANCE: invention relates to binary diglyceride derivatives of tertiary alkylamines of general formula given below, which can be used as ionisable cationic lipids for designing lipid nanoparticles for RNA delivery into cells and an organism. In said general formula, R denotes an unbranched alkyl residue of fatty acids of the limit series C7H15, C9H19, C11H23; n = 3, 4; m = 1, 3.

EFFECT: invention also relates to a lipid nanoparticle for delivery of RNA into cells and an organism, containing RNA and said binary diglyceride derivatives of tertiary alkylamines, and to its use for delivery and expression of mRNA into cells and an organism.

3 cl, 3 dwg, 2 tbl, 5 ex

Similar patents RU2823298C1

Title Year Author Number
CATIONIC LIPID FOR DELIVERY OF NUCLEIC ACIDS INTO MAMMALIAN CELLS, METHOD FOR PRODUCTION THEREOF AND USE THEREOF 2024
  • Gintsburg Aleksandr Leonidovich
  • Logunov Denis Iurevich
  • Gushchin Vladimir Alekseevich
  • Ivanov Roman Alekseevich
  • Kovalchuk Sergei Igorevich
  • Tukhvatulina Natalia Mikhailovna
  • Kleimenov Denis Aleksandrovich
  • Dzharullaeva Alina Shakhmirovna
  • Bykonia Evgeniia Nikolaevna
  • Mazunina Elena Petrovna
  • Ivanov Igor Andreevich
  • Karp Olga Edvinovna
  • Verdiev Bakhtiiar Israil Ogly
  • Pochtovyi Andrei Andreevich
  • Shcherbinin Dmitrii Nikolaevich
  • Usachev Evgenii Valerevich
  • Vasina Daria Vladimirovna
  • Tukhvatulin Amir Ildarovich
  • Dmitriev Sergei Evgenevich
  • Kuznetsova Nadezhda Anatolevna
  • Siniavin Andrei Eduardovich
  • Kozlova Sofia Rubenovna
  • Antonova Nataliia Petrovna
  • Shidlovskaia Elena Vladimirovna
  • Tutykhina Irina Leonidovna
  • Egorova Daria Andreevna
  • Remizov Timofei Andreevich
  • Zakharova Anastasiia Andreevna
  • Bogdanov Andrei Iurevich
  • Karpov Andrei Pavlovich
  • Semikhin Aleksandr Sergeevich
  • Gosudarev Andrei Igorevich
  • Tokarskaia Elizaveta Aleksandrovna
  • Lubenets Nadezhda Leonidovna
  • Vereveiko Iuliia Romanovna
  • Komiakova Marina Evgenevna
  • Erokhova Alina Sergeevna
  • Ungur Anastasiia Sergeevna
RU2836309C1
MULTI-EPITOPE POLYPEPTIDE FOR IMMUNIZATION AGAINST MYCOBACTERIUM TUBERCULOSIS 2023
  • Ivanov Roman Alekseevich
  • Reshetnikov Vasilij Vladimirovich
  • Muslimov Albert Radikovich
RU2824195C1
SORAFENIB-BASED COMBINATION THERAPY FOR HEPATOCELLULAR CARCINOMA 2022
  • Sergeeva Olga Vladimirovna
  • Abakumova Tatyana Olegovna
  • Vetosheva Polina Igorevna
  • Zatsepin Timofej Sergeevich
RU2800071C1
RNA STRUCTURES AND APPLICATION THEREOF 2021
  • Sahin, Ugur
  • Guler, Alptekin
  • Kuhn, Andreas
  • Muik, Alexander
  • Vogel, Annette
  • Walzer, Kerstin
  • Witzel, Sonja
  • Hein, Stephanie
  • Tureci, Ozlem
  • Boros, Gabor
  • Mahiny, Azita Josefine
  • Reinholz, Jonas
  • Kariko, Katalin
RU2838444C1
ANTICANCER RNA VACCINES 2017
  • Valiante, Nicholas
  • Ashburn, Ted
  • Hopson, Kristen
RU2768829C2
NUCLEIC ACID CONTAINING REGULATORY ELEMENTS OF RABBIT β-GLOBIN GENE, mtRNR1 AND EMCV 2023
  • Ivanov Roman Alekseevich
  • Reshetnikov Vasilii Vladimirovich
  • Terenin Ilia Mikhailovich
RU2831165C1
NUCLEIC ACID CONTAINING REGULATORY ELEMENTS OF RABBIT β-GLOBIN GENE, mtRNR1 AND AES 2023
  • Ivanov Roman Alekseevich
  • Reshetnikov Vasilij Vladimirovich
  • Vasileva Olga Olegovna
RU2831164C1
NUCLEIC ACID CONTAINING REGULATORY ELEMENTS H4C2, AES AND MTRNR1 2023
  • Ivanov Roman Alekseevich
  • Reshetnikov Vasilij Vladimirovich
  • Vasileva Olga Olegovna
RU2831168C1
NUCLEIC ACID CONTAINING REGULATORY ELEMENTS TPL, AES AND mtRNR1 2023
  • Ivanov Roman Alekseevich
  • Reshetnikov Vasilij Vladimirovich
  • Vasileva Olga Olegovna
RU2831163C1
TRINUCLEOTIDE CAPPING REAGENT, METHOD FOR ITS PREPARATION AND USE 2024
  • Gintsburg Aleksandr Leonidovich
  • Logunov Denis Yurevich
  • Gushchin Vladimir Alekseevich
  • Dolgushin Sergej Anatolevich
  • Shalaev Pavel Vladimirovich
  • Verdiev Bakhtiyar Israil Ogly
  • Ivanov Roman Alekseevich
  • Klejmenov Denis Aleksandrovich
  • Bykonya Evgeniya Nikolaevna
  • Mazunina Elena Petrovna
  • Dzharullaeva Alina Shakhmirovna
  • Pochtovyj Andrej Andreevich
  • Sinyavin Andrej Eduardovich
  • Usachev Evgenij Valerevich
  • Vasina Darya Vladimirovna
  • Kuznetsova Nadezhda Anatolevna
  • Dmitriev Sergej Evgenevich
  • Ivanov Igor Andreevich
  • Tutykhina Irina Leonidovna
  • Remizov Timofej Andreevich
  • Zakharova Anastasiya Andreevna
  • Semikhin Aleksandr Sergeevich
  • Gosudarev Andrej Igorevich
  • Egorova Darya Andreevna
  • Shcherbinin Dmitrij Nikolaevich
  • Tokarskaya Elizaveta Aleksandrovna
  • Lubenets Nadezhda Leonidovna
  • Tukhvatulina Natalya Mikhajlovna
RU2829515C1

RU 2 823 298 C1

Authors

Boldyrev Ivan Aleksandrovich

Shendrikov Valerij Pavlovich

Kislova Svetlana Olegovna

Andreev Dmitrij Evgenevich

Poteshnova Mariya Viktorovna

Rubtsova Mariya Petrovna

Rubtsov Yurij Petrovich

Vodovozova Elena Lvovna

Dates

2024-07-22Published

2023-11-14Filed