TRINUCLEOTIDE CAPPING REAGENT, METHOD FOR ITS PREPARATION AND USE Russian patent published in 2024 - IPC C07H21/00 C12N15/00 C12N15/11 C07H1/00 C07H1/04 A61K31/7125 A61K31/7088 

Abstract RU 2829515 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a trinucleotide capping reagent of formula

,

where R is H or Me, or a salt thereof, suitable for a transcription reaction, as well as to a complex for cotranscriptional capping of mRNA, a method for production thereof and use of a trinucleotide capping reagent for cotranscriptional capping of mRNA.

EFFECT: novel trinucleotide capping reagent is obtained, which is incorporated into the mRNA structure cotranscriptionally and provides improved efficiency of mRNA translation.

5 cl, 3 dwg, 16 ex

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Authors

Gintsburg Aleksandr Leonidovich

Logunov Denis Yurevich

Gushchin Vladimir Alekseevich

Dolgushin Sergej Anatolevich

Shalaev Pavel Vladimirovich

Verdiev Bakhtiyar Israil Ogly

Ivanov Roman Alekseevich

Klejmenov Denis Aleksandrovich

Bykonya Evgeniya Nikolaevna

Mazunina Elena Petrovna

Dzharullaeva Alina Shakhmirovna

Pochtovyj Andrej Andreevich

Sinyavin Andrej Eduardovich

Usachev Evgenij Valerevich

Vasina Darya Vladimirovna

Kuznetsova Nadezhda Anatolevna

Dmitriev Sergej Evgenevich

Ivanov Igor Andreevich

Tutykhina Irina Leonidovna

Remizov Timofej Andreevich

Zakharova Anastasiya Andreevna

Semikhin Aleksandr Sergeevich

Gosudarev Andrej Igorevich

Egorova Darya Andreevna

Shcherbinin Dmitrij Nikolaevich

Tokarskaya Elizaveta Aleksandrovna

Lubenets Nadezhda Leonidovna

Tukhvatulina Natalya Mikhajlovna

Dates

2024-10-31Published

2024-06-18Filed