METHOD OF TREATING INTERSTITIAL CYSTITIS USING MEDICINAL COMPOSITIONS Russian patent published in 2024 - IPC A61K31/167 A61K31/573 A61K31/215 A61K31/7036 A61K33/00 A61P13/10 

FIELD: medicine; urology.

SUBSTANCE: invention can be used for treating patients with interstitial cystitis. Method involves introducing a composition of medicinal preparations selected from local anesthetics, heparinoids, buffer and osmolar solutions into the bladder. Method includes two-stage introduction of two compositions of medicinal preparations with interval of 30 minutes, which is preceded by preliminary measurement of functional volume of urinary bladder. At first stage, first composition is introduced into bladder by means of urethral catheter, consisting of a preparation of a group of M-anticholinergics—Oxybutynin in amount of 5 mg, a buffer and osmotic component—Ringer's solution and a local anesthetic—2% Lidocaine, in the ratio of latter 60% to 40%, wherein the entire volume of composition is 25% of the previously measured functional volume of the bladder, with the exposure of the composition in bladder for 30 minutes. At the second stage, a second composition consisting of a synthetic glucocorticosteroid—Dexamethasone 0.4%—2 ml, an antibacterial preparation from the group of aminoglycosides is introduced into the bladder using a urethral catheter, selected from Gentamycin 40 mg/ml 2 ml or Amikacin 1 g, heparinoid—Pentosan Polysulphate from 100 to 300 mg depending on tolerance, Ringer’s solution, wherein the volume of composition is 50% of the previously measured functional volume of the bladder, with an exposure of composition for 40 minutes, in regimen 2–3 times a week, with the possibility of changing the regimen up to 1 time a week, if it is impossible to maintain regimen 2–3 times a week.

EFFECT: use of the invention enables to increase the length of the interictal period in patients with interstitial cystitis, delay the need for surgical treatment of interstitial cystitis, provides reduction or disappearance of clinical symptoms due to a sequence of using preparations aimed at pathogenetic and symptomatic components of the disease.

1 cl, 2 ex