FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing crystalline form I of chemical formula 1, in which crystalline form I is characterized by an X-ray powder diffraction pattern containing four or more diffraction peaks at values of 2θ (°) selected from 4.61±0.2, 5.49±0.2, 6.84±0.2, 11.74±0.2, 12.05±0.2, 13.74±0.2, 16.50±0.2, 16.94±0.2, 18.45±0.2, 19.11±0.2, 20.13±0.2, 20.42±0.2, 20.87±0.2, 21.57±0.2, 23.04±0.2 and 25.02±0.2. Method is carried out by dissolving salt (3S)-3-(4-(3-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)benzyloxy)phenyl)hex-4-enoic acid and L-lysine in methanol, isopropyl acetate is added to form a solid substance, isopropyl acetate is additionally added, stirred, filtered and drying the product to obtain crystalline form I of the compound of chemical formula 1.
EFFECT: crystalline form I of the compound of chemical formula 1, which exhibits excellent physical and chemical properties, such as stability, compressibility.
3 cl, 7 tbl, 14 dwg, 12 ex
[Chemical formula 1]
| Title |
Year |
Author |
Number |
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2009 |
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|
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| 4-[2-[[5-METHYL-1-(2-NAPHTHALINYL)-1H-PYRAZOL-3-YL]OXY]ETHYL]MORPHOLINE HYDROCHLORIDE POLYMORPH AND SOLVATES |
2011 |
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- Benet Bukhkhol'Ts Khordi
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|
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2019 |
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2021 |
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