CRYSTALLINE FORMS OF (R)-5-[3-CHLORO-4-(2, 3-DIHYDROXYPROPOXY)BEZ[Z]ILIDEN]-2-([Z]-PROPYLIMINO)-3-o-TOLYLTHIAZOLIDIN-4-ONE Russian patent published in 2014 - IPC C07D277/54 A61K31/426 A61P29/00 A61P37/06 A61P35/00 A61P37/00 

Abstract RU 2519548 C2

FIELD: chemistry.

SUBSTANCE: invention relates to crystalline forms of (R)-5-[3-chloro-4-(2, 3-dihydroxypropoxy)bez[z]iliden]-2-([z]-propylimino)-3-o-tolylthiazolidin-4-one, methods of their obtaining, pharmaceutical composition, containing said crystalline forms, and application of said forms as compounds, improving vascular function, and as immunomodulatory agents.

EFFECT: obtaining compounds, improving vascular function.

22 cl, 5 dwg, 5 tbl, 7 ex

Similar patents RU2519548C2

Title Year Author Number
NONHYGROSCOPIC CRYSTALLINE 5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[(2S)-2-HYDROXY-3-MORPHOLIN-4-YLPROPYL]-2,4-DIMETHYL-1H-PYRROL-3-CARBOXAMIDE MALEATE SALT, PHARMACEUTICAL COMPOSITION AND METHOD FOR CANCER TREATMENT 2004
  • Blasko Andrej
  • Tszin' Tsinvu
  • Lu Tsjun'
  • Morejdzhis Majkl Ehntoni
  • Song Dong
  • Vondervell Brenda S'Ju
RU2319702C2
POLYMORPHIC FORM OF N-[(R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)BENZAMIDE 2004
  • Matsikenas Dajnius
  • Nanninga Tomas
RU2352558C2
DERIVATIVES OF 5-(BENZ-(Z)-YLIDENE)THIAZOLIDINE-4-ONE AND APPLICATION THEREOF AS IMMUNOSUPPRESSIVE AGENTS 2004
  • Bolli Martin
  • Sherts Majkl
  • Mjuller Klaus
  • Matis Boris
  • Binkert Kristof
  • Najler Oliver
RU2379299C2
4-[2-[[5-METHYL-1-(2-NAPHTHALINYL)-1H-PYRAZOL-3-YL]OXY]ETHYL]MORPHOLINE HYDROCHLORIDE POLYMORPH AND SOLVATES 2011
  • Berenger Majmo Ramon
  • Medrano Ruperes Khorkhe
  • Benet Bukhkhol'Ts Khordi
  • Puig Fernandes Laura
  • Pellekha Pukseu Laja
RU2560150C2
NOVEL CRYSTALLINE FORMS OF SODIUM SALT OF (4-{4-[5-(6-TRIFLUOROMETHYL-PYRIDIN-3-YLAMINO)PYRIDIN-2-YL]PHENYL}CYCLOHEXYL) ACETIC ACID 2011
RU2612556C2
CRYSTALLINE FORM OF (R)-7-CHLORO-N-(QUINUCLIDIN-3-YL)BENZO[b]THIOPHENE-2-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE 2011
  • Oliver-Sheffer Patrisija
  • Shapiro Gideon
  • Chesuort Richard
  • Kisida Muneki
  • Isige Takajuki
RU2577334C2
MALEATE SALTS OF (E)-N-{4-[3-CHLORO-4-(2-PYRIDINYLMETHOXY)ANILINO]-3-CYANO-7-ETHOXY-6-QUINOLINYL}-4-(DIMETHYLAMINO)-2-BUTENAMIDE AND THEIR CRYSTALLINE FORMS 2017
  • Mirmehrabi Mahmoud
  • Cheal Gloria K.
  • Chew Warren
  • Hadfield Anthony F.
  • Ku Mannching Sherry
  • Lu Qinghong
RU2807142C1
-N-{4-[3-CHLOR-4-(2-PYRIDINYLMETHOXY)ANILINO]-3-CYANO-7-ETHOXY-6-QUINOLINYL}-4-(DIMETHYLAMINO)-2-BUTENAMIDE MALEATE SALTS AND THEIR CRYSTALLINE FORMS 2008
  • Lu Kingkhong
  • Ku Mannching Sherri
  • Chu Uorren
  • Chil Glorija K.
  • Khehdfild Ehntoni F.
  • Mirmekhrabi Makhmud
RU2463300C2
CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL][3-HYDROXY-3-(PIPERIDINE-2-YL)AZETIDINE-1-YL]METHANONE 2016
  • Brown, Adrian St. Clair
RU2762181C2
(1R*,2R*,4R*)-2-(2-{[3(4,7-DIMETHOXY-1H-BENZOIMIDAZOL-2-YL)PROPYL]METHYLAMINO}ETHYL)-5-PHENYLBICYCLO[2,2,2]OCT-5-EN-2-YL ISOBUTYRIC ACID SALTS 2009
  • Shtefan Abele
  • Stefani Kombe
  • Zhak-Aleksis Fjunel'
  • Kurt Khil'Pert
  • Fransis Juble
  • Katarina Rajkhenbehkher
  • Dorte Renneberg
  • Markus Fon Raumer
RU2516247C2

RU 2 519 548 C2

Authors

Nikolas Bonkhem

Shtefan Bukhmann

Aleks Ehberlin

Kristof Imboden

Markus Fon-Raumer

Dates

2014-06-10Published

2009-10-19Filed