FIELD: medicine; pharmaceutics.
SUBSTANCE: present invention relates to a method of treating cancer associated with prostate-specific membrane antigen (PSMA) expression. Proposed method comprises a step of administering to a host animal a therapeutically effective amount of a first compound of formula I, wherein said compound is complexed with 177Lu (I-Lu), in combination with a therapeutically effective amount of a second compound of formula I, wherein said compound is complexed with 225Ac (I-Ac). Also disclosed is the use of a compound of formula I-Lu for preparing a drug in combination with a compound of formula I-Ac.
EFFECT: as a result of treating cancer expressing PSMA, using a combination of compounds of formulas I-Lu and I-Ac, the disease is stabilized.
34 cl, 1 ex
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Authors
Dates
2024-08-28—Published
2019-09-20—Filed