NOVEL PYRIMIDINE DERIVATIVE AND COMPOSITION CONTAINING SAME FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES AND CANCER Russian patent published in 2024 - IPC C07D403/04 C07D413/14 C07D401/14 C07D403/14 C07D405/14 A61K31/506 A61K31/5377 A61K31/4155 A61P25/28 A61P25/16 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to a novel pyrimidine derivative, specifically to a compound of formula 1 or a pharmaceutically acceptable salt thereof, where each R₁' is independently selected from the group consisting of C₁-C₆alkoxy or haloC₁-C₆alkoxy; R₁'' is hydrogen or halogen; R₂ is a substituted or unsubstituted pyrazole, wherein said substituted pyrazole has, as a substitute, at least one radical selected from the group consisting of halogen, hydroxy, cyano, amino, amide, nitro, C₁-C₆alkylsulphonyl, acetyl, methyloxycarbonyl, substituted or unsubstituted C₁-C₆alkyl, substituted or unsubstituted benzyl, substituted or unsubstituted C₃-C₆cycloalkyl, substituted or unsubstituted C₃-C₆heterocycloalkyl, which refers to a cyclic saturated hydrocarbon bearing one heteroatom, such as O, as a ring member; phenyl, pyridinyl; wherein each substituted alkyl, substituted benzyl has at least one radical selected from the group consisting of halogen, hydroxy, cyano, amino, amide, nitro, C₁-C₆alkyl, C₁-C₆alkoxy, C₄-C₆heterocycloalkyl, which refers to a cyclic saturated hydrocarbon bearing at least one heteroatom, such as N or O, as a ring member; R₃ is halogen or halogenC₁-C₆alkyl; R₄ is any of structures from B-1 to B-20, from B-22 to B-29, specified in the claim, and Y is selected from a group consisting of O and S. Invention also relates to a pharmaceutical composition based on said compound.

EFFECT: obtaining alternative compounds for treating LRRK2-mediated neurodegenerative diseases and cancer.

4 cl, 3 tbl, 3 ex