FIELD: medicine; therapy.
SUBSTANCE: group of inventions relates to the field of medicine, namely to therapy; it is intended for the treatment of a rhinovirus infection or a disorder caused or exacerbated with a rhinovirus infection. A compound of (S)-N-(1-hydroxypropane-2-yl)-5-(5-(2-hydroxypropane-2-yl)-2-methyl-7-((3-(1-methyl-1H-imidazole-2-yl)benzyl)amino)pyrazolo[1,5-a]pyrimidine-3-yl)-N,2-dimethylbenzamide is presented. In another embodiment, a pharmaceutical composition containing this compound is provided. Methods for the treatment of a rhinovirus infection or treatment of a disorder caused or exacerbated with a rhinovirus infection, including administration of the specified compound, are also provided.
EFFECT: group of inventions provides a new compound of (S)-N-(1-hydroxypropane-2-yl)-5-(5-(2-hydroxypropane-2-yl)-2-methyl-7-((3-(1-methyl-1H-imidazole-2-yl)benzyl)amino)pyrazolo[1,5-a]pyrimidine-3-yl)-N,2-dimethylbenzamide, as well as a pharmaceutical composition containing this compound, which is a strong PI4KIIIβ inhibitor and is used for the treatment of a rhinovirus infection and disorders caused or exacerbated with such a virus infection.
8 cl
Title | Year | Author | Number |
---|---|---|---|
PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | 2017 |
|
RU2757457C2 |
INHIBITOR COMPOUNDS | 2013 |
|
RU2673079C2 |
NAPHTHYRIDIN DERIVATIVES AS ANTAGONISTS OF ALPHA V BETA 6 INTEGRIN FOR TREATING, IN PARTICULAR, FIBROTIC DISEASES | 2015 |
|
RU2692775C2 |
CONDENSED DERIVATIVES OF IMIDAZOLE AND PYRAZOLE AS MODULATORS OF ACTIVITY TNF | 2014 |
|
RU2687093C1 |
2-AMINOPYRASINE DERIVATIVES AS CSF-1R KINASE INHIBITORS | 2013 |
|
RU2642777C2 |
THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | 2014 |
|
RU2703273C2 |
NOVEL COMPOUNDS | 2015 |
|
RU2691389C2 |
PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS | 2019 |
|
RU2821516C2 |
SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR | 2014 |
|
RU2671212C2 |
BENZOXEPIN PI3 INHIBITORS AND METHODS FOR USING THEM | 2010 |
|
RU2557658C2 |
Authors
Dates
2023-01-30—Published
2019-01-15—Filed