P14KIII BETA INHIBITORS Russian patent published in 2023 - IPC A61K31/519 A61K31/5377 A61K31/553 A61P31/16 A61P11/00 A61P31/12 A61P43/00 C07D487/04 

Abstract RU 2789127 C2

FIELD: medicine; therapy.

SUBSTANCE: group of inventions relates to the field of medicine, namely to therapy; it is intended for the treatment of a rhinovirus infection or a disorder caused or exacerbated with a rhinovirus infection. A compound of (S)-N-(1-hydroxypropane-2-yl)-5-(5-(2-hydroxypropane-2-yl)-2-methyl-7-((3-(1-methyl-1H-imidazole-2-yl)benzyl)amino)pyrazolo[1,5-a]pyrimidine-3-yl)-N,2-dimethylbenzamide is presented. In another embodiment, a pharmaceutical composition containing this compound is provided. Methods for the treatment of a rhinovirus infection or treatment of a disorder caused or exacerbated with a rhinovirus infection, including administration of the specified compound, are also provided.

EFFECT: group of inventions provides a new compound of (S)-N-(1-hydroxypropane-2-yl)-5-(5-(2-hydroxypropane-2-yl)-2-methyl-7-((3-(1-methyl-1H-imidazole-2-yl)benzyl)amino)pyrazolo[1,5-a]pyrimidine-3-yl)-N,2-dimethylbenzamide, as well as a pharmaceutical composition containing this compound, which is a strong PI4KIIIβ inhibitor and is used for the treatment of a rhinovirus infection and disorders caused or exacerbated with such a virus infection.

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RU 2 789 127 C2

Authors

Barton Nikolas Pol

Bertran Sofi Mari

Daun Kennet Devid

Grej Metyu

Dates

2023-01-30Published

2019-01-15Filed