FIELD: biotechnology.
SUBSTANCE: what is presented is a bispecific antibody capable of simultaneously binding to PD-L1 and 4-1BB, in a heterodimeric form, structurally similar to a natural antibody. Also disclosed is an isolated polynucleotide coding said antibody. Invention also relates to the use of a bispecific antibody for treating a tumor expressing PD-L1.
EFFECT: disclosed bispecific antibody is more effective in treating tumor diseases and has fewer side effects.
21 cl, 14 dwg, 11 ex
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