FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to antibacterial compositions and can find application for treating bacterial infections caused by main multidrug-resistant gram-negative pathogens. Disclosed is use of the combination for treating bacterial infections, caused by the main multidrug-resistant gram-negative pathogens Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, Proteus spp, Citrobacter freundii, Serratia marcescens, and/or Pseudomonas aeruginosa, producing variants of beta-lactamase ESBL types TEM, SHV and/or CTX-M, which is a mixture containing a cephalosporin antibiotic cefepime, a beta-lactamase inhibitor sulbactam and an enzyme inhibitor avibactam in ratio of 4:2:1 (wt.), respectively.
EFFECT: invention provides an increase in the effectiveness of the combination of antibiotics in relation to standard strains and clinical isolates of gram-negative pathogens, including polyresistant strains producing ESBL variants of TEM, SHV and CTX-M types.
1 cl, 5 tbl
