ORALLY ADMINISTERED COMBINATIONS OF BETA-LACTAM ANTIBIOTICS AND AVIBACTAM DERIVATIVES FOR TREATING BACTERIAL INFECTIONS Russian patent published in 2024 - IPC A61K31/43 A61K31/55 A61P31/04

Abstract RU 2825281 C1

FIELD: chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to chemistry and pharmaceutical industry, namely: to a pharmaceutical composition having bactericidal activity; to an oral composition for treating bacterial infections; as well as to a method of treating a bacterial infection in a patient in need of such treatment. Disclosed pharmaceutical composition contains at least one pharmaceutically acceptable carrier medium and a therapeutically effective amount of ceftibutene or a pharmaceutically acceptable salt thereof and an avibactam derivative which is ethyl-3-((((1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl)oxy)sulphonyl)oxy)-2,2-dimethyl propanoate or a pharmaceutically acceptable salt thereof, wherein the ratio of the amount of avibactam in said avibactam derivative (or pharmaceutically acceptable salt thereof) to the amount of ceftibuten by weight ranges from 1:1 to 4:1.

EFFECT: group of inventions provides treating bacterial infections.

5 cl, 12 dwg, 16 tbl, 4 ex

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RU 2 825 281 C1

Authors

Trias, Joakim

Sejbl, Kerol

Nikolls, Endryu

Dates

2024-08-23—Published

2020-08-27—Filed