FIELD: chemistry.
SUBSTANCE: present group of inventions refers to adoptopathy. Disclosed are chimeric receptors of antigen (CAR) containing a mesothelial-binding domain, as well as nucleic acids, a vector and a cell coding them. What is also presented is a method for producing T-cells and cell populations, as well as methods for providing anticancer immunity and methods of treating a disease associated with mesotheliene expression.
EFFECT: this group of inventions can find further application in cancer therapy.
92 cl, 48 dwg, 17 tbl, 18 ex
| Title |
Year |
Author |
Number |
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2017 |
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2017 |
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|
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2015 |
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|
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2015 |
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|
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2015 |
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|
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2015 |
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|
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| CD20 THERAPY, CD22 THERAPY AND COMBINATION THERAPY WITH CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR (CAR) K CD19 |
2016 |
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- Brogdon, Jennifer
- Dakappagari, Naveen, Kumar
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|
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2015 |
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|
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| METHODS OF PRODUCING CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR |
2019 |
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|
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| COMPOSITIONS AND METHODS OF SELECTIVE PROTEIN DEGRADATION |
2018 |
- Golosov, Andrei
- Goold, Carleton, Proctor
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|
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