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(19)

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2 714 902

(13)

(51)

IPC

C12N15/13(2006-01-01)

A61K39/395(2006-01-01)

A61K35/17(2015-01-01)

A61K47/68(2017-01-01)

C07K19/00(2006-01-01)

C12N5/10(2006-01-01)

C12N15/63(2006-01-01)

C07K14/725(2006-01-01)

(21) (22)

Application

2016129125, 2014-12-19

(24)

Start date

2014-12-19

(22)

Actual filing date

2014-12-19

(45)

Published

2020-02-20

(72)

Inventor

Bitti GregoriEngels BorisIdamakanti NeeradzhaDzhun Karl Kh.Lev AndreasSun KhuejtszyuanU Tsilun

(73)

Holder

Novartis AgDze Trastiz Of Dze Yuniversiti Of Pensilvaniya

CHIMERIC HUMAN MESOTHELIOGEN ANTIGEN RECEPTORS AND USE THEREOF Russian patent published in 2020 - IPC C12N15/13 A61K39/395 A61K35/17 A61K47/68 C07K19/00 C12N5/10 C12N15/63 C07K14/725

Abstract RU 2714902 C2

FIELD: chemistry.

SUBSTANCE: present group of inventions refers to adoptopathy. Disclosed are chimeric receptors of antigen (CAR) containing a mesothelial-binding domain, as well as nucleic acids, a vector and a cell coding them. What is also presented is a method for producing T-cells and cell populations, as well as methods for providing anticancer immunity and methods of treating a disease associated with mesotheliene expression.

EFFECT: this group of inventions can find further application in cancer therapy.

92 cl, 48 dwg, 17 tbl, 18 ex

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RU 2 714 902 C2

Authors

Bitti Gregori

Engels Boris

Idamakanti Neeradzha

Dzhun Karl Kh.

Lev Andreas

Sun Khuejtszyuan

U Tsilun

Dates

2020-02-20—Published

2014-12-19—Filed