QUINOLINE DERIVATIVES FOR USE IN TREATING INFLAMMATORY DISEASES Russian patent published in 2024 - IPC A61K31/47 A61K31/4709 A61K31/497 A61K31/5377 C07H17/02 A61P29/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: present invention relates to medicine and pharmaceutics and discloses the use of a compound of formula (Ib') or any of its metabolites, or a pharmaceutically acceptable salt thereof, as well as a compound of formula (IVb'), as well as a specific compound specified below, or a pharmaceutically acceptable salt thereof for the treatment of an inflammatory disease, disorder or condition selected from (a) an inflammatory disease, disorder or condition of the liver selected from non-alcoholic steatohepatitis, non-alcoholic fatty liver disease, cholestatic liver disease and sclerosing cholangitis; and (b) an inflammatory disease, disorder or condition of the lung selected from chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary hypertension and sarcoidosis. In general formulas (Ib') and (IVb'), each R independently represents a halogen atom or a group selected from (C₁-C₃) fluoroalkoxy groups, groups –NR₁R₂, (C₁-C₄)alkoxy groups, -O-P(═O)(OR₃)(OR₄) groups, (C₁-C₃)alkyl group, a NO₂ group, or a group of formula (IIa), or a group of formula (IIIa), each of R₁ and R₂ independently represents hydrogen or (C₁-C₃)alkyl; each of R₃ and R₄ independently represents hydrogen, Li⁺, Na⁺, K⁺, N⁺(Ra)₄ or benzyl; n is 1 or 2; each R' independently represents hydrogen, (C₁-C₃)alkyl, hydroxyl, halogen, -NO₂, -NR₁R₂, morpholinyl, morpholino, N-methylpiperazinyl, (C₁-C₃)fluoroalkyl, (C₁-C₄)alkoxy, -O-P(═O)-(OR₃)(OR₄), -CN, -NH-SO₂-N(CH₃)₂ group, a group of formula (IIa), or a group of formula (IIIa), A is a covalent bond, oxygen or NH; B is a covalent bond or NH; m is 2, 3 or 4; p is 1, 2 or 3; each of Ra and Rb is independently hydrogen, (C₁-C₅) alkyl or (C₃-C₆) cycloalkyl, or Ra and Rb together with the nitrogen atom to which they are attached form saturated 5- or 6-membered heterocycle, where said heterocycle optionally contains an additional heteroatom selected from N, O, S, where said heterocycle is optionally substituted with one or more Ra, and R" is hydrogen, (C₁-C₄) alkyl or a group of formula (IIa).

EFFECT: quinoline derivatives for use in treating inflammatory diseases are disclosed.

12 cl, 5 dwg, 13 tbl, 4 ex