FIELD: biotechnology.
SUBSTANCE: disclosed is a method of producing a recombinant polypeptide containing two chains, such as an immunomobilizing monoclonal anti-cancer T-cell receptor (ImmTAC) containing an alpha chain and a beta chain in an E. coli host cell.
EFFECT: invention provides a novel method for recombinant production of properly folded and assembled double-stranded proteins in prokaryotic host cells on an industrial scale.
23 cl, 65 dwg, 4 tbl, 8 ex
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Year |
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|
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|
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