FIELD: medicine.
SUBSTANCE: group of inventions relates to immunology and oncology. What is developed is an immunobiological agent based on mRNA, in which the mRNA contains a sequence selected from: SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 8, at 5'-end; an open reading frame encoding from 1 to 80 tumour gene signatures; sequence SEQ ID NO: 6 or SEQ ID NO: 7 at 3'-end. Also disclosed is a method for preparing the agent and use thereof.
EFFECT: presented group of inventions extends the range of agents and methods for inducing immune response in patients with oncological diseases and can be used in therapy of patients with oncological diseases of various aetiologies.
5 cl, 4 dwg, 1 tbl, 8 ex
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| METHOD FOR FORMING IMMUNE SURVEILLANCE SYSTEM FOR TUMOUR CELLS IN MAMMAL BODY | 2024 |
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RU2828654C1 |
| mRNA-BASED VECTOR FOR INCREASED TARGET PROTEIN PRODUCTION IN MAMMALIAN CELLS (VARIANTS) | 2022 |
|
RU2792231C1 |
| IMMUNOBIOLOGICAL AGENT AND METHOD FOR USE THEREOF TO INDUCE SPECIFIC IMMUNITY AGAINST EBOLA VIRUS | 2015 |
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RU2578159C1 |
| mRNA-BASED IMMUNOBIOLOGICAL AGENT FOR PREVENTION OF DISEASES CAUSED BY TICK-BORNE ENCEPHALITIS VIRUS | 2024 |
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RU2823754C1 |
| ARTIFICIAL NUCLEIC ACID MOLECULES | 2013 |
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| PLASMID pVAX-RBD DNA MATRIX OF mRNA-RBD MOLECULES, OBTAINED USING THE pVAX - RBD DNA MATRIX, PROVIDING THE SYNTHESIS AND SECRETION OF THE RBD PROTEIN SARS-CoV 2 IN MAMMALIAN CELLS AND A COMPLEX IN THE FORM OF NANOPARTICLES CONTAINING mRNA-RBD MOLECULES THAT INDUCE SARS-CoV-SPECIFIC ANTIBODIES WITH VIRAL NEUTRALIZING ACTIVITY | 2021 |
|
RU2754230C1 |
| MTS GENE, MUTATIONS OF THIS GENE AND METHODS OF DIAGNOSIS OF MALIGNANT TUMORS USING MTS GENE SEQUENCE | 1995 |
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RU2164419C2 |
| AGENTS LINKING FRIZZLED RECEPTOR AND THEIR USE | 2009 |
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| PLASMIDS CODING VERSIONS OF PROTEIN p185 SEQUENCE, AND THEIR THERAPEUTIC APPLICATION | 2005 |
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| ARTIFICIAL MOLECULES OF NUCLEIC ACID | 2014 |
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