ARTIFICIAL NUCLEIC ACID MOLECULES Russian patent published in 2018 - IPC C12N15/67 C12N15/85 C12N15/88 A61K48/00

Abstract RU 2651498 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to an artificial nucleic acid molecule. Synergetic effect provided by the presence of 3'-UTR of an albumin gene and the 3-untranslated region of the mRNA, placed in the secondary stem-loop sequence, in the structure of the artificial nucleic acid sequence, allows to increase the stability and prolong the expression of the encoded protein.

EFFECT: invention further relates to the use of such an artificial nucleic acid molecule, encoding therapeutic peptides or proteins in medicine for gene therapy and/or genetic vaccination.

63 cl, 23 dwg, 5 ex, 14 tbl

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RU 2 651 498 C2

Authors

Tess Andreas

Kallen Karl-Jozef

Dates

2018-04-19—Published

2013-03-27—Filed