COMPOUNDS AND DERIVATIVES OF SUBSTITUTED HYDROXYSTILBENE, SYNTHESIS AND USE THEREOF Russian patent published in 2024 - IPC C07C41/30 C07C43/23 C07C51/367 C07C65/19 C07C201/12 C07C205/37 C07C209/68 C07C211/45 C07C227/16 C07C279/18 C07C303/40 C07C311/08 C07C319/20 C07C231/12 C07C233/25 C07D235/26 C07D263/58 A61K31/05 A61K31/135 A61K31/155 A61K31/18 A61K31/192 A61K31/4184 A61K31/423 A61P17/00 A61P17/06 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for synthesis of a compound of formula (I):

where R^1a is independently allyl, crotyl, prenyl or benzyl; R^1b is independently CF₃, OR² or NHR³; R^1c is H; R^1d is independently an OH, O-protecting group, NO₂ or NHR³; R^1b and R^1d are not identical; R^1e is independently C₁-C₆ alkyl, OH, OR², NO₂, NHR³, NMeR³ or SR²; R^1f is independently H, OH, O-protective group, NO₂, NHR³, NHC=NH(NH₂), N(OH)(CO)Me or COOH; R^1g is independently H, C₁-C₆ alkyl or OH; and not more than one of R^1f or R^1g can be H; R³ is independently H, CH₃, (CO)H, (CO)Me, SO₂Me, CH₂COOR², CO(CH₂)_nNH₂ or CO(CH₂)_nCOOH, where n is 0, 1 or 2; or R^1e and R^1f form a five-membered heterocyclic ring containing a carbonyl group, when R^1e is independently OH, NH₂ or NHMe, and R^1f is NH₂, so that nitrogen in R^1f is bridged through a carbonyl group with oxygen or nitrogen in R^1e, and R^1g is H; R² is independently methyl, ethyl, propyl, isopropyl, butyl, isobutyl, trifluoromethyl or O-protective group, when R² is attached to O. This method involves a step of combining a compound of formula (II) (module A) with a compound of formula (III) (module B) to obtain a compound of formula (IV) (module C):

In the compound of formula (II), X is a halogen or a hydroxyl group, where the halogen is selected from the group consisting of F, Cl, Br, I and At, in the compound of formula (IV) R⁴ is C₁-C₆ alkyl. Invention also relates to a compound of formula (I) and to methods of treating cancer, atopic dermatitis and psoriasis using said compound or a pharmaceutical composition containing said compound.

EFFECT: creation of a new process which provides effective and industrially applicable production of number of 2-substituted hydroxystilbene compounds, are promising for use in treating cancer and diseases or disorders of the skin.

33 cl, 18 dwg, 8 tbl