FIELD: organic chemistry; pharmacology; medicine.
SUBSTANCE: invention relates to a modified nucleoside analogue of formula (I) or a pharmaceutically acceptable salt thereof, where R is selected independently and represents -C≡C-C3-6-cycloalkyl, -C≡C-C3-6-cycloalkenyl, -C≡C-C6-aryl substituted with -C≡C-C6-aryl with at least one substitute selected from partially or completely halogenated -C1-5-alkyl, phenyl substituted with at least one substitute selected from -C1-5-alkyl, partially or completely halogenated -C1-5-alkyl. Invention also relates to use of a compound of formula (I) as a virus reproduction inhibitor related to genus Flavivirus, use of a compound of formula (I) for preparing a pharmaceutical composition for treating and/or preventing diseases caused by a virus of the genus Flavivirus, and a pharmaceutical composition based on the compound of formula (I) for the treatment and/or prevention of diseases caused by a virus of the genus Flavivirus.
EFFECT: obtaining a compound of formula (I), characterized by high efficiency in inhibiting reproduction of viruses of the genus Flavivirus.
12 cl, 4 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MIMETICS OF POLY (ADP-RIBOSE) AND PROCESS FOR PRODUCING THEREOF | 2011 |
|
RU2559873C2 |
| AGENT FOR INHIBITING THE HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME BASED ON PENTAFURANOSYL NUCLEOSIDE DERIVATIVES | 2019 |
|
RU2748103C1 |
| MEDICATION FOR INHIBITING HUMAN ENZYME POLY(ADP-RIBOSE)POLYMERASE-1 | 2009 |
|
RU2411948C1 |
| 7-METHYL-2'-DEOXYGUANOSINE HYDROIODIDE SALT AS SUBSTRATE FOR PRODUCING 2'-DEOXYNUCLEOSIDES BY METHOD OF ENZYME TRANSGLYCOSYLATION | 2017 |
|
RU2664472C1 |
| NEW HEPATOPROTECTIVE AGENTS AND METHODS FOR PREPARING THEM | 2023 |
|
RU2815370C1 |
| COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | 2007 |
|
RU2525392C2 |
| COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | 2007 |
|
RU2466729C2 |
| METHOD OF PRODUCING N-[3-OXO-20(29)LUPEN-28-OIL]-ω-AMINO ACIDS | 2019 |
|
RU2684288C1 |
| ANTI-TUBERCULOSIS AGENTS BEING 3,7-DISUBSTITUTED [1,2,4]TRIAZOLO[1,5-b][1,2,4,5]TETRAZINES | 2022 |
|
RU2802300C1 |
| SUBSTITUTED ISOXAZOLES, PHARMACEUTICAL COMPOSITIONS BASED THEREON HAVING ANTIVIRAL ACTIVITY, AND METHOD FOR USE THEREOF | 2018 |
|
RU2733945C2 |
