FIELD: chemistry.
SUBSTANCE: invention relates to organic and medicinal chemistry, pharmacology and medicine, specifically to a compound of general formula (I) or a pharmaceutically acceptable salt thereof, where R1 is selected independently and represents: NH-(C1-5-alkyl)-(1-adamantyl); NH-(C1-5-alkyl)-(2-adamantyl); NH-(C1-5-alkyl)-OH; 
; R2 is selected independently and represents: C3-6-cycloalkyl, isopropyl, alternatively R2 is methyl, if R1 is ; n takes values 0-2. Invention also relates to a compound of general formula (II) or a pharmaceutically acceptable salt thereof, where if R'1 is selected independently and represents: NH-(C1-5-alkyl)-(1-adamantyl); NH-(C1-5-alkyl)-(2-adamantyl); then R'2 is selected independently and represents hydrogen, methyl, -NH2, halogen; alternatively, if R'1 is selected independently and represents: 
; 
; 
; then R'2 is selected independently and represents methyl, -NH2, halogen; n takes values 0-2. Invention also relates to a pharmaceutical composition based on said compounds and use thereof as an inhibitor of reproduction of a virus belonging to the genus Orthoflavivirus.
EFFECT: design and production of compounds characterized by high efficiency in inhibiting reproduction of viruses of the genus Orthoflavivirus, particularly tick-borne encephalitis virus, yellow fever virus, West Nile virus and others.
11 cl, 4 tbl
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| SUBSTITUTED ISOXAZOLES, PHARMACEUTICAL COMPOSITIONS BASED THEREON HAVING ANTIVIRAL ACTIVITY, AND METHOD FOR USE THEREOF | 2018 |
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RU2733945C2 |
| PYRIDOXINE DERIVATIVES WITH NONLINEAR OPTICAL PROPERTIES | 2012 |
|
RU2501801C1 |
| QUATERNARY AMMONIUM COMPOUNDS BASED ON DERIVATIVES OF PYRIDOXINE AND FATTY CARBOXYLIC ACIDS WITH ANTIBACTERIAL ACTIVITY | 2022 |
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RU2795265C1 |
| BIS-AMMONIUM COMPOUNDS BASED ON PYRIDOXINE, HAVING ANTIBACTERIAL AND ANTIMYCOTIC PROPERTIES | 2020 |
|
RU2731999C1 |
| ADENOSINE DERIVATIVES-INHIBITORS OF REPRODUCTION OF VIRUSES RELATED TO GENUS FLAVIVIRUS | 2023 |
|
RU2828777C1 |
| METHOD OF PRODUCING 3',4',5,6-TETRAHYDRO-1H-SPIRO[PYRIDINE-4,5'-THIENO[2,3-d]PYRIMIDINE] DERIVATIVES | 2011 |
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RU2455306C1 |
| ANTIRETROVIRAL AGENTS BASED ON AZIDOTHYMIDINE DERIVATIVES | 2014 |
|
RU2561501C1 |
| ALICYCLIC COMPOUNDS, A METHOD OF THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION SHOWING ANTI-INFLAMMATORY ACTIVITY AND A METHOD OF TREATMENT OF PATIENTS WITH INFLAMMATION | 1994 |
|
RU2130011C1 |
| METHOD OF PRODUCING N-ADAMANTYLATED AMIDES | 2013 |
|
RU2549901C1 |
| METHOD FOR PREPARING 5,8,9,10-TETRAHYDROPYRIMIDINO[4,5-d]AZOCINE DERIVATIVES HAVING TRIFLATE, SECONDARY AND TERTIARY AMINO GROUPS IN 4-TH POSITION | 2011 |
|
RU2478637C2 |
