PROTEIN SIGNATURE FOR DIAGNOSING COLORECTAL CANCER OR ITS PRECANCEROUS STAGE Russian patent published in 2024 - IPC G01N33/68 G01N33/574 

FIELD: medicine.

SUBSTANCE: presented group of inventions relates to oncology. There are presented methods for in vitro diagnostics of colorectal cancer or its precancerous stage. Disclosed is use of combinations Flt3L and CYFRA21-1, or Flt3L and CYFRA21-1 and AREG, or Flt3L and CYFRA21-1 and AREG and ErbB4, or Flt3L and CYFRA21-1 and AREG and CLEC2C in vitro in a biological sample obtained from a patient for the diagnosis of colorectal cancer or its precancerous stage and a corresponding set of elements and use thereof for the diagnosis of colorectal cancer or its precancerous stage.

EFFECT: proposed group of inventions provides high sensitivity and specificity of diagnosing colorectal cancer or its precancerous stage by identifying a combination Flt3L and CYFRA21-1, or Flt3L and CYFRA21-1 and AREG, or Flt3L and CYFRA21-1 and AREG and ErbB4, or Flt3L and CYFRA21-1 and AREG and CLEC2C in a biological sample obtained from a subject.

9 cl, 8 dwg, 12 tbl, 2 ex