FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. A method for detecting advanced colorectal adenomas in humans is described, comprising the steps of: measuring an overall profile or expression level of one or more microRNAs derived from one or more biological samples of a subject, wherein at least one of these microRNAs is miR18a; and comparing an overall expression profile of one or more microRNAs from a biological sample of a subject with expected advanced colorectal adenomas with an overall expression profile of one or more microRNAs from a biological sample of a normal subject, where the normal subject is a healthy human who does not suffer from advanced colorectal adenomas, and where the overexpression of miR18a indicates the presence of advanced colorectal adenomas.
EFFECT: invention provides wider range of means for detecting advanced colorectal adenomas in humans.
11 cl, 4 dwg, 6 tbl
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| TEST SYSTEM “miR-M-SCREEN” FOR PREDICTING THE DEVELOPMENT OF METASTASES IN PATIENTS WITH COLORECTAL CANCER BASED ON THE LEVEL OF miR-26a AND miR-143 MICRO-RNA IN BLOOD PLASMA | 2022 |
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| IMPROVED METHOD OF SCREENING, DIAGNOSING AND/OR MONITORING ADVANCED COLORECTAL NEOPLASIA, ADVANCED ADENOMA AND/OR COLORECTAL CANCER | 2020 |
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