FIELD: biotechnology.
SUBSTANCE: disclosed is a composition of a probiotic agent for therapy and prevention of pathological conditions occurring against the background of disturbed regulation of interactions of the "intestine–brain" axis, containing a lyophilisate of living cells of two probiotic strains of bacterial cultures Bifidobacterium longum subsp. longum VKM B-3717D and Lacticaseibacillus paracasei subsp. paracasei VKM B-3711D in sugar-gelatine medium or in skim milk with addition of N-acetylglucosamine or lacto-N-biose (C14H25NO11) before lyophilization to final concentration in the medium of not less than 0.1 mg/ml and all or one of components—30 mg of chitosan, 50 mg of sucrose, 70 mg of lactose, placed in one penicillin bottle or in 1 enteric gelatinous capsule No. 3, wherein 1 therapeutic dose contains 7·107 CFU of viable strains Bifidobacterium longum subsp. longum VKMB-3717D and Lacticaseibacillus paracasei subsp. paracasei VKMB-3711D.
EFFECT: invention extends the range of probiotic agents having antagonistic activity on pathogenic, opportunistic microorganisms.
1 cl, 4 dwg, 7 tbl, 10 ex
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