FIELD: medicine.
SUBSTANCE: present invention relates to nuclear medicine and molecular imaging, and in particular, it relates to a dual-targeting compound, a method for preparing and using it. Disclosed is a dual targeting compound of formula (I), a dual targeting compound capable of labelling with a radionuclide, having a structure of formula (I-1) or formula (I-2).
EFFECT: dual targeting compound according to the present invention has high affinity to the FAP target and the integrin αvβ3 target, can target a FAP target and an integrin αvβ3 target in a synergistic manner in tumours, and also exhibits high tumour absorption and long retention time in the tumour; in addition, the present invention discloses a dual-targeting radionuclide-labelled compound, a method for production thereof and use of said compound in preparing medicinal agents for diagnosing or treating diseases characterized by overexpression of FAP and/or integrin αvβ3.
11 cl, 16 dwg, 4 ex
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