FIBROBLAST ACTIVATION PROTEIN INHIBITOR, MODIFIED BY TRUNCATED BLUE EVANS, METHOD FOR PREPARATION AND USE THEREOF Russian patent published in 2025 - IPC C07D401/14 A61K31/4709 A61K31/547 A61K51/04 A61P35/00 A61K103/00 A61K103/30 

Abstract RU 2841304 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound which is a fibroblast activation protein inhibitor modified with truncated blue YEVAN, or a pharmaceutically acceptable salt thereof, wherein its structure is represented by formula (II-1). Invention also discloses a method of producing a compound of formula (II-1), methods of producing a radiolabelled complex based on compound of formula (II-1) and use of formula (II-1) in preparing drugs for radionuclide therapy or imaging tumours with high level of expression of FAP protein.

EFFECT: proposed compound and a radioactive label based on the structure of said compound are characterized by a considerably prolonged half-life in the bloodstream, as well as increased absorption, accumulation and retention time in the tumour, and are suitable for nuclide therapy and imaging of tumours with a high level of FAP expression.

6 cl, 23 dwg, 1 ex

(II-1)

Similar patents RU2841304C2

Title Year Author Number
DUAL TARGETING COMPOUND FOR FIBROBLAST ACTIVATION PROTEIN (FAP) AND INTEGRIN αβ, METHOD FOR PRODUCTION AND USE THEREOF 2023
  • Chen, Xiaoyuan
  • Xu, Pengfei
  • Wu, Xiaoming
  • Guo, Zhide
  • Yang, Qingbao
  • Wen, Xuejun
RU2838403C1
COMPOUND HAVING TARGETED EFFECT ON PROSTATE-SPECIFIC MEMBRANE ANTIGEN, METHOD FOR PRODUCTION THEREOF AND USE THEREOF 2022
  • Chen, Xiaoyuan
  • Xu, Pengfei
RU2832300C2
DUAL TARGETING COMPOUND, METHOD FOR ITS PREPARATION AND USE 2022
  • Chen, Xiaoyuan
  • Xu, Pengfei
  • Wu, Xiaoming
  • Guo, Zhide
  • Yang, Qingbao
  • Wen, Xuejun
RU2838179C2
FAP INHIBITOR 2019
  • Khaberkorn, Uve
  • Loktev, Anastasiya
  • Linder, Tomas
  • Mier, Valter
  • Gizel, Frederik
  • Kratochvil, Klemens
RU2797409C2
NEW PSA-BINDING AGENTS AND THEIR USE 2018
  • Benesova Martina
  • Mueller Cristina
  • Umbricht Christoph
  • Schibli Roger
  • Zhernosekov Konstantin
RU2787105C2
CONJUGATED BISPHOSPHONATES FOR DIAGNOSING AND TREATING BONE DISEASES 2015
  • Resh Frank
  • Mekkel Marian
RU2742660C2
RADIOLABELLED GRPR ANTAGONIST FOR USE AS THERAPEUTIC AND DIAGNOSTIC AGENT 2020
  • Mariani, Maurizio F.
  • Orlandi, Francesca
  • Wegener, Antje
  • Chicco, Daniela
RU2839888C1
NOVEL TUMOR ANTIGEN BINDING AGENTS AND USE THEREOF 2019
  • Benesova Martina
  • Mueller Cristina
  • Umbricht Christoph
  • Schibli Roger
  • Zhernosekov Konstantin
  • Deberle Luisa Maria
RU2831681C2
BOMBESIN ANALOGUE PEPTIDE ANTAGONIST CONJUGATES 2009
  • Khel'Mut Mehkke
  • Zhan Klod Rebi
  • Rozal'Ba Mansi
RU2523531C2
GRPR ANTAGONISTS FOR DETECTING, DIAGNOSING AND TREATING GRPR-POSITIVE ONCOLOGICAL DISEASE 2013
  • Maina-Nok Teodosiya
  • Nok Bertkhold Artur
  • De Jong Khendriks Marion
RU2693465C2

RU 2 841 304 C2

Authors

Chen, Xiaoyuan

Xu, Pengfei

Guo, Zhide

Wu, Xiaoming

Yang, Qingbao

He, Tian

Dates

2025-06-05Published

2021-07-11Filed