ANTIBACTERIAL CALCIUM-PHOSPHATE COATINGS ON ALLOYS WITH VANCOMYCIN AND DOPAMINE IMPREGNATION Russian patent published in 2024 - IPC A61L27/32 A61L27/34 A61L27/54 

FIELD: chemistry; performing operations.

SUBSTANCE: invention relates to hybrid antibacterial coatings on alloys for biocompatible implants with targeted drug delivery and can be used in implant surgery. Disclosed is a method of producing a hybrid antibacterial calcium-phosphate PEO coating on an electrolyte alloy by plasma-electrolytic oxidation in a combined bipolar mode: in potentiometric mode at voltage of 380 V during anodic polarization and in galvanodynamic mode at current intensity varying from 5 to 3 A during cathodic polarization. Electrolyte contains 25 g/l of calcium glycerophosphate (C₃H₇CaO₆P), 5 g/l of sodium fluoride (NaF) and 7 g/l of sodium metasilicate (Na₂SiO₃). Obtained sample with the calcium phosphate PEO coating is washed under vacuum 2 times with 70 % ethyl alcohol and 2 times with distilled water, dried at room temperature and immersed in a polymerisation solution consisting of a TRIS-HCl buffer with pH 8.5, with 2 mg/ml of dopamine and 5 mg/ml of vancomycin dissolved in it, which is stirred at room temperature for 2 hours, with further air drying for 4-6 hours.

EFFECT: method provides high adhesion strength of the hydroxyapatite coating, high deposition thereof, wherein the obtained coating has excellent biocompatibility, anti-inflammatory activity and antibacterial properties.

1 cl, 1 dwg, 1 ex