SERINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS Russian patent published in 2019 - IPC C07K5/65 C07D471/04 A61K38/00 A61K31/437 A61P5/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I)

,

in which: A is phenyl, naphthyl or pyridyl; X is CH or N; R¹ are independently selected from group comprising (1) hydrogen, (2) halogen, (3) C_1-6 alkyl, where alkyl is unsubstituted or substituted with one or more substitutes independently selected from halogen, (4) -OC_1-6 alkyl, where alkyl is unsubstituted, and (5) -CN; R² is hydrogen or C_1-6 alkyl, where alkyl is unsubstituted or substituted with one or more substitutes independently selected from halogen; p is 1 or 2; or a pharmaceutically acceptable salt thereof.

EFFECT: compounds can be used in therapy as modulator of secretion growth hormone receptor (also called ghrelin receptor or GHSRla receptor).

25 cl, 7 tbl, 28 ex