3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ZINC FINGER PROTEIN 2 (IKZF2) OF THE IKAROS FAMILY Russian patent published in 2023 - IPC C07D401/04 C07D401/14 A61K31/454 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to a compound of formula (I') having the properties of an inhibitor of the IKAROS family zinc finger protein 2 (IKZF2), or a pharmaceutically acceptable salt thereof, a pharmaceutical composition based on them for the treatment of a disease or disorder affected by a decrease in IKZF2 protein levels, a method for destroying IKZF2, a method for modulating and reducing IKZF2 protein levels, a method of treatment and their use in the treatment of a disease or disorder affected by modulation of IKZF2 protein levels. In the general formula (I') each of X₁ and X₂ independently represents H or halogen; _Rx is H;

R₁ is either or The remaining values of the radicals are indicated in the claims.

EFFECT: obtaining an inhibitor of the IKAROS family zinc finger protein 2 (IKZF2), or a pharmaceutically acceptable salt thereof.

30 cl, 14 tbl, 185 ex