MODIFIED CYANINE DYES AND THEIR CONJUGATES Russian patent published in 2025 - IPC C07D471/18 C07D417/14 C07D403/12 C07D209/14 A61K49/00 A61K39/00 C07K7/52 C07K16/28 C09B23/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I)

(I),

where R1 and R2 are independently -CO-NH-Y group, where Y is selected from linear or branched C₁-C₈ alkyl substituted with two to five hydroxyl groups; R3 is a linear or branched C₄ alkyl substituted with a group -SO₃H; R4 is a linear divalent C₅ alkyl; R5 is selected from -CONH-; S is a spacer selected from -(CH₂)_p- and -NH(CH₂CH₂O)_pCH₂CH₂-, where p is integer from 0 to 4; T is a target group selected from the group consisting of a small molecule, a protein, a peptide, a peptidomimetic and an antibody or fragment thereof; n is an integer equal to 3; and m is an integer equal to 0 or 1, as well as to a pharmaceutical diagnostic composition, a diagnostic kit and an intermediate compound of formula (II)

where R1, R2, R3, R4 and n are as defined in cl. 1, and R5' selected from -COOH, -CONH₂, -COO-Pg and -CONH-Pg, where Pg is a protective group, such as a C_1-2 alkyl group.

EFFECT: novel compounds are obtained, which can be used for determination and demarcation of a tumor boundary in directed surgery of an individual patient.

13 cl, 4 dwg, 8 tbl, 17 ex