CONJUGATE OF RGD-PEPTIDES AND PHOTOSENSITISERS OF PORPHYRIN OR (BACTERIO)CHLOROPHYLL AND APPLICATION THEREOF Russian patent published in 2012 - IPC C07K7/06 C07F1/08 C07F3/02 C07F13/00 C07F15/00 A61K41/00 A61K31/28 A61K47/48 

FIELD: medicine.

SUBSTANCE: invention refers to photosensitisers, namely to a conjugate of RGD-containing peptide or RGD-peptidomimetic and a photosensitiser selected from tetraarylporphyrin of formula:

or chlorophyll or tbacteriochlorophyll of formulae , or wherein tetraarylporphyrin or said chlorophyll or bacteriochlorophyll derivative of formula I, II or III contains at least one residue of the RGD-containing peptide or RGD-peptidomimetic. The values of M and radicals is related with those specified in the patent claim. Also, there are offered a pharmaceutical composition, a diagnostic technique for tumours by dynamic fluorescent visualisation, molecular magnetic resonant tomography (MPT) for diagnosing tumours and a method of photodynamic therapy of tumours.

EFFECT: invention provides producing the conjugate of the RGD-containing peptide or RgD-peptidomimetic and the photosensitiser which is applied in methods of photodynamic therapy and diagnosing of tumours.

23 cl, 75 dwg, 43 ex, 5 tbl