FIELD: medicine.
SUBSTANCE: group of inventions relates to an inhalation device for forming an aerosol from two liquid compositions, variants of a method for treating a subject suffering from a disease using an inhalation device, use of a combination of the first and second liquid compositions in a method for treating a subject suffering from a disease using an inhalation device, a first reservoir containing a first liquid composition containing beta-a long-acting agonist, and a second reservoir containing a second liquid composition, designed to be used with an inhalation device, use of an inhalation device or a first reservoir containing a first liquid composition containing a long-acting beta agonist, and a method of delivering two liquid compositions to a subject. Inhalation device comprises a first and second tanks containing liquid compositions, and is an inhaler operated by a pump, configured to release, upon actuation, a measured dose of the first liquid composition from the first tank and a measured dose of the second liquid composition from the second tank. First and second liquid composition storage tanks communicate with the first and second injection chambers to create a first pressure inside the first injection chamber and a second pressure inside the second injection chamber. Device has a first and second feeding tubes for inserting the inner end facing the tank into the first and second discharge chambers. Internal volume of the first and second discharge chambers changes due to the movement of the first and second discharge chambers to the first and second supply tubes. Device has a first outlet area and a second outlet area configured to emit the first and second liquid compositions separately from the inhalation device. Device includes a first potential energy storage unit connected to one end of the first injection chamber, and a second potential energy storage unit connected to one end of the second injection chamber. Each of the first and second feeding tubes is fixed and attached to the inhalation device and/or to the first and second outlet regions, and each of the first and second injection chambers is configured to move relative to the inhalation device and/or the first and second outlet regions. Use of an inhalation device is intended for the treatment or prevention of a disease. In the first variant, the treatment method includes a step of administering an effective amount of two active ingredients to a subject using an inhalation device. In the second variant, the treatment method includes a step of administering an effective amount of two liquid compositions, each containing an active ingredient, to a subject using an inhalation device. Delivery method includes the stage of providing an inhalation device. In using a combination of the first and second liquid compositions in a method of treating a subject suffering from asthma or COPD, the first and second liquid compositions are administered to the subject using an inhalation device. First reservoir contains a first liquid composition containing a long-acting beta agonist, and the second reservoir contains a second liquid composition containing an inhaled corticosteroid. First and second tanks are designed to be used with an inhalation device. Use of an inhalation device is intended for the manufacture of a drug or medical device for the treatment of a subject who needs it due to a disease.
EFFECT: providing an improved method of delivering liquid solutions having different properties and/or incompatible ingredients to a patient by inhalation, which eliminates one or more disadvantages of currently known methods of inhalation therapy, providing an inhalation device that allows such an improved method of delivery.
37 cl, 1 dwg
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Authors
Dates
2025-01-28—Published
2021-03-29—Filed