FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to a polynucleotide coding a protein containing a sequence of a mutant soluble ActRIIB-ECD (activin receptor PV-extracellular domain) polypeptide, as well as a vector and a cell containing said polypeptide. Also disclosed is a method of producing mutant ActRIIB protein, involving culturing said cell.
EFFECT: invention is effective for treating diseases associated with muscular atrophy.
16 cl, 12 dwg, 8 tbl, 8 ex
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