MELANOCYTE-REGULATING PEPTIDES Russian patent published in 2025 - IPC C07K7/08 A61K38/10 A61K8/64 A61P35/00 A61P17/00 A61Q19/02 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, particularly to melanocyte-related disorders. Disclosed are melanocyte-regulating peptides, pharmaceutical and cosmetic compositions containing them as active ingredients, as well as their use for regulation of melanogenesis, treatment or prevention of melanoma and diseases associated with disturbed regulation of melanogenesis. Peptide has an amino acid sequence (Trp)_m-(Asn)_n-Lys-Gly-Thr-Ile-Leu-Lys-Ala-Ser-Val-Asp-Tyr-Ile-Arg-Lys-(Leu)_p-(Gln)_q (SEQ ID NO: 1) or (Arg)_mx-(Arg)_nx-Arg-Arg-Phe-Asn-Ile-Asn-Asp-Arg-Ile-Lys-Glu-Leu-Gly-Thr-Leu-(Ile)_px-(Pro)_qx (SEQ ID NO: 2). Peptide further includes a linker biradical "L" of formula (I) -[(R₁)_a-(R₂)-(R₃)_b]_c- (I), which is a compound of the alpha carbon atom of the amino acid located in the "i" position with the alpha carbon atom of the amino acid located in the position "I + 7" in peptide sequence. Amino acids, which are connected by a linker, have the formula .

EFFECT: disclosed peptides regulate melanogenesis either by promoting or reducing melanin production, inhibit proliferation of malignant melanocytes, allow effective regulation of melanocyte activity not only with respect to melanin formation, but also with respect to cell proliferation, and can be effective for treating pigment disorders.

15 cl, 1 dwg, 4 tbl