METHOD OF PRODUCING 2-[1-ETHYLSULPHONYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]AZETIDIN-3-YL]ACETONITRILE Russian patent published in 2025 - IPC C07D487/04 

Abstract RU 2835441 C1

FIELD: chemistry.

SUBSTANCE: invention refers to medicine, pharmacology and chemical-pharmaceutical industry, namely to a method of producing a compound of formula (I). Method is carried out by reacting a compound of formula (II)' with an organic fluorine-containing acid in a mixture of solvents, which is a mixture of an aprotic organic solvent with water in a volume ratio of 1.0:10.0-10.0:1.0, respectively, and a mixture of bases consisting of an inorganic base selected from a group comprising hydroxides of alkali, alkali-earth metals or ammonium, or hydrates thereof, and alkylamine, in molar ratios of inorganic base to alkylamine from 1.0:0.1 to 1.0:10.0.

EFFECT: disclosed method enables to obtain a compound of formula (I) with high output and purity.

9 cl, 1 dwg, 2 tbl, 2 ex

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RU 2 835 441 C1

Authors

Belyi Petr Aleksandrovich

Lopatukhin Eduard Iurevich

Korolev Vladimir Lvovich

Zaslavskaia Kira Iakovlevna

Belov Evgenii Iurevich

Dates

2025-02-25Published

2024-05-02Filed