Show metadata Hide metadata

(19)

(11)

2 837 221

(13)

(51)

IPC

C07D487/04(2006-01-01)

A61K31/519(2006-01-01)

A61P17/14(2006-01-01)

A61P19/02(2006-01-01)

A61P37/00(2006-01-01)

A61P37/08(2006-01-01)

A61Q7/00(2006-01-01)

(21) (22)

Application

2024138088, 2024-12-17

(24)

Start date

2024-12-17

(22)

Actual filing date

2024-12-17

(45)

Published

2025-03-27

(72)

Inventor

Belyi Petr AleksandrovichLopatukhin Eduard IurevichKorolev Vladimir LvovichZaslavskaia Kira IakovlevnaBelov Evgenii IurevichKazaishvili Iurii GeorgievichShcherbakova Viktoriia Sergeevna

(73)

Holder

Obshchestvo S Ogranichennoi Otvetstvennostiu Rus"

NOVEL PYRROLOPYRIMIDINE DERIVATIVES Russian patent published in 2025 - IPC C07D487/04 A61K31/519 A61P17/14 A61P19/02 A61P37/00 A61P37/08 A61Q7/00

Abstract RU 2837221 C1

FIELD: chemistry.

SUBSTANCE: group of inventions relates to a compound of formula A''

or pharmaceutically acceptable salts thereof, as well as a pharmaceutical composition, and a medicinal agent containing same, and use for preparing a medicinal agent for treating autoimmune diseases by inhibition of Janus kinase.

EFFECT: improved compared to (1-(2-hydroxy-ethanesulphonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]-azetidin-3-yl)-acetonitrile selectivity with respect to inhibition of JAK enzymes.

11 cl, 2 dwg, 3 tbl, 5 ex

Similar patents RU2837221C1

Title	Year	Author	Number
NOVEL PYRROLOPYRIMIDINE DERIVATIVES	2024	Belyi Petr Aleksandrovich Lopatukhin Eduard Iurevich Korolev Vladimir Lvovich Zaslavskaia Kira Iakovlevna Belov Evgenii Iurevich Kazaishvili Iurii Georgievich Shcherbakova Viktoriia Sergeevna	RU2837548C1
NOVEL PYRROLOPYRIMIDINE DERIVATIVES	2024	Belyi Petr Aleksandrovich Lopatukhin Eduard Iurevich Korolev Vladimir Lvovich Zaslavskaia Kira Iakovlevna Belov Evgenii Iurevich Kazaishvili Iurii Georgievich Shcherbakova Viktoriia Sergeevna	RU2837216C1
NOVEL PYRROLOPYRIMIDINE DERIVATIVES	2024	Belyi Petr Aleksandrovich Lopatukhin Eduard Iurevich Korolev Vladimir Lvovich Zaslavskaia Kira Iakovlevna Belov Evgenii Iurevich Kazaishvili Iurii Georgievich Shcherbakova Viktoriia Sergeevna	RU2837316C1
NOVEL PYRROLOPYRIMIDINE DERIVATIVES	2024	Belyi Petr Aleksandrovich Lopatukhin Eduard Iurevich Korolev Vladimir Lvovich Zaslavskaia Kira Iakovlevna Belov Evgenii Iurevich Kazaishvili Iurii Georgievich Shcherbakova Viktoriia Sergeevna	RU2837533C1
NOVEL PYRROLOPYRIMIDINE DERIVATIVES	2024	Belyi Petr Aleksandrovich Lopatukhin Eduard Iurevich Korolev Vladimir Lvovich Zaslavskaia Kira Iakovlevna Belov Evgenii Iurevich Kazaishvili Iurii Georgievich Shcherbakova Viktoriia Sergeevna	RU2837215C1
{3-[(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)AZOLYL]AZETIDIN-3-YL} ACETONITRILES AS JANUS KINASE INHIBITORS	2015	Ivashchenko Aleksandr Vasilevich Ignatev Vasilij Gennadevich Repik Aleksej Evgenevich Shafeev Mikhail Ajratovich	RU2601410C1
METHOD OF PRODUCING 2-[1-ETHYLSULPHONYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]AZETIDIN-3-YL]ACETONITRILE	2024	Belyi Petr Aleksandrovich Lopatukhin Eduard Iurevich Korolev Vladimir Lvovich Zaslavskaia Kira Iakovlevna Belov Evgenii Iurevich	RU2835441C1
METHOD OF PRODUCING 2-[1-ETHYLSULPHONYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]AZETIDIN-3-YL]ACETONITRILE	2024	Belyi Petr Aleksandrovich Lopatukhin Eduard Iurevich Korolev Vladimir Lvovich Zaslavskaia Kira Iakovlevna Belov Evgenii Iurevich	RU2835443C1
METHOD OF PRODUCING 2-[1-ETHYLSULPHONYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]AZETIDIN-3-YL]ACETONITRILE	2024	Belyi Petr Aleksandrovich Lopatukhin Eduard Iurevich Korolev Vladimir Lvovich Zaslavskaia Kira Iakovlevna Belov Evgenii Iurevich	RU2835445C1
TREATMENT OF HYDRADENITIS WITH JAK INHIBITORS	2020	Fensome, Andrew Gerstenberger, Brian Stephen Owen, Dafydd Rhys	RU2805595C1

RU 2 837 221 C1

Authors

Belyi Petr Aleksandrovich

Lopatukhin Eduard Iurevich

Korolev Vladimir Lvovich

Zaslavskaia Kira Iakovlevna

Belov Evgenii Iurevich

Kazaishvili Iurii Georgievich

Shcherbakova Viktoriia Sergeevna

Dates

2025-03-27—Published

2024-12-17—Filed